Thus, it has been found that in this case the retro-Michael reaction is accompanied by 28-demethoxylation and partially by 28-demethoxy-methylation.doi:10.1007/BF00630170L. é. OdinokovaM. V. DenisenkoV. A. DenisenkoN. I. Uvarova
The MBH reaction involves formally a sequence of Michael addition, aldol reaction, and a retro-Michael reaction (β-elimination) as shown in Scheme 2. Michael addition of a Lewis base catalyst to the electron-deficient alkene generates enolate 4, which can react with an aldehyde to yield the ...
In the course of Michael addition of carbanions, derived from malononitrile or cyanoacetic ester, to a nitrostyrol retro reaction has also been observed. Depending on the reaction conditions any of the two compounds formed can be obtained as main product. The entire process has been thoroughly ...
Studies on the reaction of some 1,5-ketodiesters/1,5-diketones with NaX (X = Cl/Br/I)/DMSO have shown that under microwave/thermal conditions, facile retro -Michael addition (RMA) reaction takes place instead of formation of the expected Krapcho products. Mechanistic studies have shown that...
An organocatalytic asymmetric cascade Michael/hemiketalization/retro-aldol reaction between unsaturated pyrazolones and α-nitroketones is described. A bifunctional thiourea catalyst was found to be efficient for this reaction. With 10 mol % of catalyst, high yields as well as excellent enantioselectivit...
Asymmetric Organocatalytic Cascade Michael/Hemiketalization/Retro-Aldol Reaction of 2-[ (E)-2-Nitrovinyl]phenols with 2,4-Dioxo-4-arylbutanoates:A Convenient Access to Chiral α-Keto Esters. Liu, Y,Wang, Y.,Song, H.,Zhou, Z.,Tang, C. Advanced Synthesis & Catalysis . 2013...
Boncel S, Ma.czka M, Walczak KZ (2010) Michael versus retro- Michael reaction in the regioselective synthesis of N-1 and N-3 uracil adducts. Tetrahedron 66:8450-8457. doi:10.1016/j. tet.2010.08.059Boncel, S.; Ma˛czka, M.; Walczak, K.Z. Michael versus retro-Michael reaction in ...
retro-Michael reactionThe reaction of dialkyl ethoxymethylidenemalonates with arylamides of acetoacetic acid was studied for the purpose of creating a new method for the synthesis of substituted 2-pyridones containing a carbamoyl group. This reaction was shown to occur in the presence of ...
ChemInform Abstract: Retro‐Michael Reaction in the Regioselective Synthesis of α‐ Alkyl‐β,γ‐enones.alkylation, arylation, dealkylation, dearylation, C‐acylation, olefinationketones (benzene compounds)ChemInform is a weeklying Service, delivering concise information at a glance that was extracted ...
MHzThe investigation of the scope and limitation of retro-Micheal reaction of 1,5-dicarbonyl compounds showed that the reaction worked well for I,5-diketones and 1,5-ketoaldehydes but gave poor yield for 1,5-ketoesters and 1,5-ketoacids.Wang, JXLi, TS中国化学快报(英文版)...