Tandem Retro-Michael Addition-Claisen Rearrangement-Intramolecular Cyclization: One-Pot Synthesis of Densely Functionalized Ethyl Dihydropyrimidine-4-carboxylates from Simple Building Blocksretro-Michael additionClaisen rearrangementintramolecular cyclization
Studies on the reaction of some 1,5-ketodiesters/1,5-diketones with NaX (X = Cl/Br/I)/DMSO have shown that under microwave/thermal conditions, facile retro -Michael addition (RMA) reaction takes place instead of formation of the expected Krapcho products. Mechanistic studies have shown that...
Palladium on carbon (10% Pd/C) efficiently catalyzes the (retro-)Michael addition of activated methylene compounds 2ad, such as malononitrile (2b), to mono- and doubly activated styrenes 1ah to give the adducts 3al. The scope and limitations are described. The Knoevenagel condensation reaction ...
uinine using ESI-MS Study of michael-michael-retro michael addition catalyzed by 9-amino-9-deoxyepiquinine using ESI-MSStudy of michael-michael-retro michael addition catalyzed by 9-amino-9-deoxyepiquinine using ESI-MSSpectroscopic database
In the course of Michael addition of carbanions, derived from malononitrile or cyanoacetic ester, to a nitrostyrol retro reaction has also been observed. Depending on the reaction conditions any of the two compounds formed can be obtained as main product. The entire process has been thoroughly ...
Michael addition of a Lewis base catalyst to the electron-deficient alkene generates enolate 4, which can react with an aldehyde to yield the zwitterionic intermediate 5. A proton shift from the α-carbon atom to the β-alkoxide in the ketone 5, followed by β-elimination of the Lewis base...
本研究基于绿色合成,发展了催化的α,β-不饱和羰基化合物分别与苯并咪唑类杂环水相aza-Michael加成反应以及与芳香b-二酮的Michael addition/retro-Claisen condensation串联反应,从而高效合成新型苯并咪唑衍生物和1,5-二羰基酯类化合物.苯并咪唑类结构单元作为一类重要的含氮杂环,广泛应用于药物,超分子和有机功能材料...
单位代码 10635 学 号 112013316001159 硕士学位论文 -不饱和羰基化合物 aza-Michael addition反应和 Michael/retro-Claisen condensation 串联反应的绿色合成研究 论文作者:文静 指导教师:蔡桂鑫 副教授 学科专业:有机化学 研究方向:生物有机药物化学 提交论文日期:2016 年 04 月 19 日 论文答辩日期:...
Getting in the groove, the squad explores games centered on music or musicians. Included in this medley are titles such as Michael Jackson's Moonwalker, Tempo, and Parappa The Rapper. Greg also discovers a guitar legend, and the squad unanimously votes against collect-a-thons. ...
A number of novel tandem sequences initiated by a retro-aldol process are described along with preliminary scope and limitation studies. These include (i) retro-aldol/Wittig trapping/intramolecular Michael addition, (ii) retro-aldol/aza-Wittig/intramolecular imine addition, (iii) retro-aldol/Henry/...