RETRO-MANNICH REACTION1-AZA-ADAMANTANESPHLOROGLUCINOLS5-CHLORO-RESORCINOLSThe first triple (Grob) fragmentation is described. The process (mechanism) involves retro-Mannich reactions. Easily accessible 1-aza-adamantane derivatives 1 are converted to substituted 5-chloro-resorcinols 5 ....
Synthesis of title compounds (4a-j) was carried out by following aminomethylation Mannich reaction. Test compounds were effective in inhibiting edema induc... M Akhter,A Husain,N Akhter,... - 《Indian Journal of Pharmaceutical Sciences》 被引量: 16发表: 2011年 Thin-layer chromatographic analysis...
Mannich retro oxo azabicyclooctenecarboxylate pyrrole prepnretro Mannich Grob fragmentation oxo azabicyclooctenecarboxylatetropenone oxo azabicyclooctenecarboxylate retro Mannich reactionFor Abstract see ChemInform Abstract in Full Text.doi:10.1002/ejoc.200300804Nicolai Cramer...
We would add that a theoretical analysis would greatly help to explain why a retro-Michael reaction is favored to a retro-Mannich reaction as the initial step of this transformation. Sign in to download full-size image Scheme 2. Lastly, the original transformation the authors intended to ...
Under acidic conditions tryptophan sidechains crosslink to form delta1,delta1'-tryptophan dimers through a Mannich-type mechanism. Tryptophan dimers are readily cleaved at high temperatures under acidic conditions making it impossible to isolate tryptophan dimers under standard conditions of acidic protein ...
theexactreverseofasyntheticreaction,toatargetstructure.Corey&Cheng,TheLogicofChemicalSynthesis,1989.• 断裂转化和反合成子 (TransformsandRetrons)HH H H Carbo-Diels-AlderTransform HH H H H H H H H H MeCOOMe MeCOOMeMeCOOMe H COOMe H COOMe MeOOC 断裂转化（）断裂转化（1）TGT ...
4. anti-Selective Direct Catalytic Asymmetric Mannich-type Reaction of Hydroxyketone to Provide anti-beta-Amino Alcohols [C] . Naoya Kumagai, Shinji Harada, Shigeki Matsunaga, Symposium on Organometallic Chemistry . 2003 机译:羟基酮的抗选择性直接催化不对称曼尼希型反应提供抗β-氨基醇 ...
A highly efficient asymmetric ring-opening/cyclization/retro-Mannich reaction of cyclopropyl ketones with aryl 1,2-diamines has been realized using a chiral N, N′-dioxide/ScIII catalyst. Benzimidazoles containing chiral side chains were generated under mild reaction conditions in ex...
A highly efficient asymmetric ring-opening/cyclization/retro-Mannich reaction of cyclopropyl ketones with aryl 1,2-diamines has been realized using a chiral N,N′-dioxide/ScIII catalyst. Benzimidazoles containing chiral side chains were generated under mild reaction conditions in excellent outcomes (up...
mannich reactiontropenonesN-protected tropenone 4 undergoes highly regioselective re-tro-Mannich reactions to 2-pyrrolyl ketones 5 and 7 in the presence of Lewis or Br0nsted acids. Analogously, the pyrrole derivative 8a was obtained by using subsequent nucleophilic trapping with TMSCN....