Cells that show chiasma failure (leading to multi- valent disruption) were scored separately (Fig. 4e; Tables 2 and 3) as well as those showing spontaneous chromosome breakage (Table 2). Frequencies of abnormal MI cells ranged between 18.5 and 64.2%, the main component being non-alternate ...
It was found that oscillations both during exit from meiosis and during mitosis acted to increase the number of inner cell mass cells. In contrast, the trophectoderm cell number was largest in ethanol-activated parthenotes and smallest in fertilized embryos. Postimplantation development was also ...
This association is sustained through mitosis and leads to a significant increase in supernumerary centrosomes, abnormal spindle poles, and chromosomal segregation defects. Chlamydial infection thus can lead to chromosome instability in cells that recover from infection. 展开 关键词: centrosome Chlamydia ...
In miR-34a overexpressing cultures, a mitotic cell in metaphase (white arrow) is evident among the differentiating cells. Scale bar: 10 μm. (c) Quantification of cells in mitosis (left) and in apoptosis (right) of transduced cultures at different DIV. In the early DIV, miR-34a transduced...
Last, ectopic expression of FBXL2 significantly inhibited the growth and migration of tumorogenic cells and tumor formation in athymic nude mice. These observations implicate SCFFBXL2as an indispensible regulator of mitosis that serves as a tumor suppressor. 展开 ...
This assay allows the detection of micronuclei that arise from chromosomal fragments that are not incorporated into daughter nuclei at mitosis and thus reflect genomic disruption (Heddle, 1973, Kalweit et al., 1999, Kersten et al., 2002). The proportion of binucleated cells with micronuclei was ...
Effects of cellular mitosis on the apparent diffusion coefficient of synchronized HeLa cells IntroductionThe apparent diffusion coefficient (ADC) of self-diffusing water molecules in biological tissue is reduced from that of a simple solution as a result of restrictive barriers. Consequently, the attenuat...
Overexpression of human PELO in Hep2G cells had prominent effect on cell growth, cytoskeleton organization and cell spreading. To find proteins interacting with PELO, full-length human PELO cDNA was used as a bait in a yeast two-hybrid screening assay. Partial sequences of HAX1, EIF3G and S...
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Somatic mutations of the receptor tyrosine kinase Flt3 consisting of internal tandem duplications (ITD) occur in 20% of patients with acute myeloid leukemi... M Mizuk...
S100A7 gene is found to be responsible for anoikis resistance and tumorigenicity in human oral cancer cells. We have observed up-regulation of S100A7 in anoikis resistant cell lines, orthotropic model and patients samples with head and neck cancer. It is also noticed that secretion of S100A7 pr...