Interleukin-1beta produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy. Diabetes 2011; 60:248-57.Bertin-Maghit S,Pang D,O’’Sullivan B, et al.Interleukin-1β ...
Response to Letter Regarding Article, 鈥淚nhibition of Interleukin-1尾 Decreases Aneurysm Formation and Progression in a Novel Model of Thoracic Aortic Aneurysm鈥 Ailawadi, Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms, Circulat...
Interleukin-1beta () is one of several cytokines known to also influence the reproductive axis. inhibits the hypothalamo-pituitary-gonadal (HPG) axis by suppressing and gonadal steroid production. Because several pituitary cell types, including follistatin-producing folliculo-stellate cells, are targets...
The present studies were undertaken to determine whether interleukin 1β ([IL-1] 1.0 μg/kg, ip) pretreatment for 3 days impairs the adaptive response to sucrose feeding in rats. One week after the last IL-1 injection, when no differences in plasma glucose and serum immunoreactive insulin (...
(MHC) antigens, whereas interactions between cytotoxic T lymphocytes and their target involve MHC class I antigens.17Soluble mediators or cytokines are secreted by all cell types and serve as activation and differentiation factors for different cell lineages. These include interleukins, interferons, ...
(HLA-A)*02+subjects with advanced RCC with IMA901 in two consecutive studies. In the phase 1 study, the T cell responses of the patients to multiple TUMAPs were associated with better disease control and lower numbers of prevaccine forkhead box P3 (FOXP3)+regulatory T (Treg) cells. The...
et al. Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation. Plos ONE 15, e0238484 (2020). Article CAS PubMed PubMed Central Google Scholar Dower, S. K. et al. The cell surface receptors for interleukin-1α and interleukin-1β are identical. ...
The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. The sex differences in the skeletal muscle transcriptome in both the resting state and following anabolic stimuli, such as resistance
(TGR5). The activation of TGR5 by TCA may upregulate the expression of the inhibitory receptor programmed death 1 (PD1) on CD8+T cells via suppression of the production of interleukin-1212,45,46and downregulate the expression of the activating receptor NKG2D on NK cells via induction of the ...
Influenza infection increases the incidence of myocardial infarction but the reason is unknown. Platelets mediate vascular occlusion through thrombotic functions but are also recognized to have immunomodulatory activity. To determine if platelet processe