(1) intrinsic factors, which include the ontogeny of adult TRMs consisting of a specific combination of cells derived from both embryonic precursors and adult monocytes; and (2) extrinsic local factors, which are unique to the TRM niche of residence, including the presence of local inflammation5...
Leukocytes and endothelial cells frequently cooperate to resolve inflammatory events. In most cases, these interactions are transient in nature and triggered by immunological insults. Here, we report that, in areas of disturbed blood flow, aortic endothe
2. Lineage-determining transcription factors and the core macrophage program 3. Niche signals and signal-dependent transcription factors 4. Refining the niche hypothesis: intra-organ local and inter-organ similar niches 5. The importance of nature and nurture in functional specialization 6. Conclusion ...
A lineage of myeloid cells independent of Myb and hematopoietic stem cells Science, 336 (2012), pp. 86-90 CrossrefView in ScopusGoogle Scholar Scott et al., 2014 C.L. Scott, S. Henri, M. Guilliams Mononuclear phagocytes of the intestine, the skin, and the lung Immunol. Rev., 262 (...
Determinants of Resident Tissue Macrophage Identity and Function (2) local factors unique to the niche of residence, evolving during development and aging; (3) inflammation status; and (4) the cumulative effect of time spent in a specific tissue that contributes to the resilient adaptation of .....
(2) extrinsic local factors, which are unique to the TRM niche of residence, including the presence of local inflammation5. When considering local factors, recent findings suggest that TRMs are not merely passive recipients of signals from their local microenvironment. Rather, they also actively ...
invading pathogens while in parallel tolerating harmless particulate matter and sustaining its vital function. A pivotal safeguard of this balance is the local lung tissue microenvironment consisting of the respiratory epithelium and a sophisticated network of non-circulating lung-resident immune cells [1]...
et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336, 86–90 (2012). Article ADS CAS PubMed Google Scholar Leader, A. M. et al. CITEseq analysis of non-small-cell lung cancer lesions reveals an axis of immune cell activation associated with ...
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against pathogens and malignancies, and the molecular processes that lead to TRM cell formation are therefore of substantial biomedical interest. Prior work has demonstrated
A direct comparison of the cell-intrinsic ability of YS-Macs, FL-MOs, and BM-MOs to colonize a given macrophage niche and to generate self-maintaining tissue-resident macrophages has never been performed. Moreover, it remains to be tested whether these cells would be equally competent in ...