As stem cells (SCs) in adult organs continue to be identified and characterized, it becomes clear that their survival, quiescence, and activation depend on specific signals in their microenvironment, or niche. Although adult SCs of diverse tissues differ by their developmental origin, cycling ...
Stem cell niches are specialized microenvironments that promote the maintenance of stem cells and regulate their function. Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and niche cells, sys...
An adult stem cell has often been defined in a negative fashion. For instance, for years adult stem cells were considered by many to be stem cells that werenotembryonic stem cells. This way of thinking was too broad. It ended up including induced pluripotent stem cells or iPS cells in the...
Automated 3D analysis of confocal images derived from SVZ whole mounts has provided an extensive, quantitative description of the elements of the adult stem cell niche. The 3D viewpoint revealed important information about the structure of the adult SVZ, the arrangement of its constituent cells, and...
The intestinal crypt is an anatomically distinct structure that makes up the stem cell niche in many species, including mice and humans, and adult stem cells (ASCs) within the niche are located at the crypt base and marked byLgr5 expression35,36. We specifically assessed the presence, abundan...
The existence of adult renal stem cells has long been suspected because the kidney is capable of regeneration in response to injury, such as acute tubular necrosis (ATN), but their location, or niche, has not been fully defined yet. The aim of this study was to identify the niche of adul...
This review focuses on these advances, specifically in the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition we review recent research on the concept of stem cell niche, and its relevance to adult mesenchymal stem cells....
- 《Cell Stem Cell》 被引量: 425发表: 2011年 Thymosin beta4 increases hair growth by activation of hair follicle stem cells. These keratinocytes originate in the hair follicle bulge region, a niche for skin stem cells. Rat vibrissa follicle clonogenic keratinocytes, closely related,... D ...
Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal. Neural stem cells persist in the adult mammalian brain, within the subventricular zone (SVZ). The endogenous mechanisms underpinning SVZ neural stem cell p... C Nicoleau,O...
Large-scale live imaging of adult neural stem cells in their endogenous niche Live imaging of adult neural stem cells (aNSCs) in vivo is a technical challenge in the vertebrate brain. Here, we achieve long-term imaging of the adult z... Dray,Nicolas,Bedu,... - 《Journal of Cell Science...