Human skin wound repair may result in various outcomes with most of them leading to scar formation. Commonly seen in many cutaneous wound healing cases, hypertrophic scars are considered as phenotypes of abnormal wound repair. To prevent the formation of hypertrophic scars, efforts have been made ...
Typically, human wounds heal by forming non-functional fibrotic tissue, commonly referred to as a scar. Among fibroproliferative conditions, keloid and hypertrophic scarring are well-known. These abnormal scars tend to develop in specific areas, such as the anterior chest, shoulder, scapula, and l...
Research Highlights11 Dec 2024Nature Reviews Clinical Oncology P: 1 Moving towards more personalized approaches in locally advanced and metastatic colorectal cancer Colorectal cancer remains a challenging heterogeneous disease with substantial morbidity and mortality. However, progressive advances over the past...
Astrocytes regulate glial scar formation in cerebral ischemic stroke Yang Ting, Ding Zhibin, Jiang Nan, Han Hongxia, Hou Miaomiao, Ma Cungen, Song Lijuan, Li Xinyi [Abstract][Full text] Single-cell RNA sequencing reveals the heterogeneity of astrocytes ...
Researchers outline how cells activate to cause fibrosis and organ scarring New research led by Unity Health Toronto that examines how fibroblast cells in the body are activated to cause fibrosis and organ scarring has been published in Nature Reviews Molecular Cell Biology. Fibrosis and organ scar...
Real-time PCR and western blotting assay verified that miR-181b-5p enhanced the protein kinase B (PKB, also known as AKT) activity and improved downstream factor transcription. Furthermore, miR-181b-5p effectively ameliorated the inhibition of HPDLSC proliferation and promoted HPDLSC induced by ...
Adipose-derived stem cells (ADSCs) have been extensively used in preclinical and clinical trials for treating various diseases. However, the differences between ADSCs from lean individuals (L-ADSCs) and those from obese individuals (O-ADSCs) have not bee
RPE cells (NCT02590692). This study demonstrated safety and tolerability in legally blind patients with dry AMD [41,42]. However, graft survival remains a significant challenge, influenced by factors like aging of Bruch's membrane, subretinal scarring, para-inflammation, and choroid ischemia [33]...
The CAM could constantly reproduce all stages in human wound healing, including inflammation, re-epithelisation, angiogenesis, fibronectin deposition and scar formation. During wound healing on the CAM, chorionic epithelium hyperplasia and macrophage inflammatory infiltration can be observed with tripled ...
Cryosurgery has disadvantages such as scarring, difficulty in assessing recurrence, and a lack of tissue diagnosis or proof of tumor clearance. For small histologically confirmed SCC, good short-term cure rates have been achieved but a prior biopsy is necessary to establish the diagnosis histologicall...