Typically, human wounds heal by forming non-functional fibrotic tissue, commonly referred to as a scar. Among fibroproliferative conditions, keloid and hypertrophic scarring are well-known. These abnormal scars tend to develop in specific areas, such as the anterior chest, shoulder, scapula, and l...
Regeneration of injured skin and peripheral nerves requires control of wound contraction, not scar formation. Wound Repair Regen. 2017;25:177–91. Article PubMed PubMed Central Google Scholar Jiang W, Xu J. Immune modulation by mesenchymal stem cells. Cell Prolif. 2020;53:e12712. Article ...
Ferroptosis is an iron-related form of programmed cell death. Accumulating evidence has identified the pathogenic role of ferroptosis in multiple orthopedic disorders. However, the relationship between ferroptosis and SONFH is still unclear. In addition,
One study showed that H19 effectively recruited the m6A reader YTHDF1, which significantly promoted the translation of SCARB1 and facilitated angiogenesis, specifically in gastric cancer [44]. The lncRNA ZNRD1-AS1 was reported to promote the proliferation, migration, and angiogenesis of malignant ...
If the detection of HR gene alteration is regarded as the discovery of the HRD status from the perspective of the cause, then the genomic scar analysis can determine the status of the genomic defect from the phenomenon. Genomic scar analysis as a direct and comprehensive way of predicting the...
Electrospin Silk-Collagen Scaffolds and BMP-14 for Ligament and Tendon Repair and Regeneration Maghdouri-White Y et al. 2018. Biomed Phys & Eng Exp. https://orcid.org/0000-0002-2010-2165 Application: Tendon Regenerative ligament and tendon repair scaffolds have been highly researched, yet ...
According to these tests, the safety of the IMRCs has been verified as required by the National Institutes for Food and Drug Control (NIFDC) in China. Fig. 5: Evaluation of the safety of IMRC transfusion. a t-SNE projection of single cells and their pluripotency gene expression amongst IM...
(TLC) followed by reversed phase HPLC that EtBr binds specifically with the PDRN fraction of the multi-component extract. The binding specificity of EtBr has been verified by the analysis of emission spectra of the extract. A concentration of 0.29 μg/ml EtBr exhibits a linear range of ...
Human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs) exhibit the potential to repair the injured heart after myocardial infarction (MI) by promoting neovascularization and cardiomyocyte survival. However, because of the low cellular retention and poor engraftment efficacy, cell therapy...
Epicardial epithelial-to-mesenchymal transition (EMT) plays a pivotal role in both heart development and injury response and involves dynamic cellular changes that are essential for cardiogenesis and myocardial repair. Specifically, epicardial EMT is a c