( 1995 ) Sickle cell anemia: basic research reaches the clinic . New England Journal of Medicine , 332 , 1372 – 1374 .Schechter , Alan N. , Rodgers , Griffin P. , . (1995) Sickle Cell Anemia — Basic Research Reaches the Clinic. New England Journal of Medicine 332 :20, 1372-1374...
Sickle cell anemia (SCA) is associated with a chronic proinflammatory state characterized by elevated leukocyte count, mortality from severe recurrent infections, and subsequent vasoocclusive complications with leukocyte adhesion to the endothelium and increased plasma levels of inflammatory cytokines. The ...
Brain network hypersensitivity underlies pain crises in sickle cell disease Pangyu Joo Minkyung Kim Ying Wang ResearchOpen Access27 Mar 2024Scientific Reports Volume: 14, P: 7315 Risk factors for acute chest syndrome among children with sickle cell anemia hospitalized for vaso-occlusive crises ...
Studies on child growth and development have always occupied an important position in the scientific research curriculum and are of interest to the researchers of both Medical Science and Physical Anthropology all over the world. Sickle Cell Anemia (SCA) is a hereditary anemia, predominantly seen amo...
aIn 1949, the sickle-cell anemia of the research for a genetic one enzyme hypothesis for a further rise in a single gene a peptide 1949年,研究的镰刀细胞贫血症为一个基因一个酵素假说为进一步上升在一个唯一基因肽[translate]
Parvovirus B19 infection causes transient aplastic crisis in sickle cell disease (SCD) due to a temporary interruption in the red blood cell production. Toxicity from hydroxyurea includes anemia and reticulocytopenia, both of which also occur during a transient aplastic crisis event. Hydroxyurea inhibits...
The molecular medicine perspective emphasizes cellular and molecular phenomena and interventions rather than the previous conceptual and observational focus on patients and their organs. In November, 1949, with the seminal paper, "Sickle Cell Anemia, a Molecular Disease", in Science magazine, Linus ...
Fetal hemoglobin values with one exception were found elevated (> 2) in 89 patients with sickle-cell anemia and the mean level of Hb F was of 11.45 %. In 47 of these patients Hb F was more than 10 % by Singer's method. Hemoglobin and/or hematocrit values were not correlated with the...
The Multicenter Study of Hydroxyurea in Sickle Cell Anemia is a randomized double-blind placebo-controlled trial to test whether hydroxyurea can reduce the rate of painful crises in adult patients who have at least three painful crises per year. The sample size of 299 patients yields at least 90...
Institute of Medicine Committee on Understanding Eliminating Racial Ethnic Disparities in Health Care. Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care. National Academies Press; 2002. 64. Sickle cell anemia, a race specific disease. JAMA. 1947;133(1):33-34. doi:10.1001...