Sickle cell anemia--basic research reaches the clinic. N Engl J Med. 1995;332:1372-1374.Schechter , Alan N. Rodgers , Griffin P. . (1995) Sickle Cell Anemia — Basic Research Reaches the Clinic. New England Journal of Medicine 332 :20, 1372-1374 ${xml_link: 10.1056%2FNEJM...
Sickle cell anemia (SCA) is associated with a chronic proinflammatory state characterized by elevated leukocyte count, mortality from severe recurrent infections, and subsequent vasoocclusive complications with leukocyte adhesion to the endothelium and increased plasma levels of inflammatory cytokines. The ...
Risk factors for acute chest syndrome among children with sickle cell anemia hospitalized for vaso-occlusive crises Faisal A. Alghamdi Fawaz Al-Kasim Rehab Alluqmani ResearchOpen Access12 Mar 2024Scientific Reports Volume: 14, P: 5978 Development of pathophysiologically relevant models of sickle cell...
aIn 1949, the sickle-cell anemia of the research for a genetic one enzyme hypothesis for a further rise in a single gene a peptide 1949年,研究的镰刀细胞贫血症为一个基因一个酵素假说为进一步上升在一个唯一基因肽[translate]
Fetal hemoglobin values with one exception were found elevated (> 2) in 89 patients with sickle-cell anemia and the mean level of Hb F was of 11.45 %. In 47 of these patients Hb F was more than 10 % by Singer's method. Hemoglobin and/or hematocrit values were not correlated with the...
Institute of Medicine Committee on Understanding Eliminating Racial Ethnic Disparities in Health Care. Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care. National Academies Press; 2002. 64. Sickle cell anemia, a race specific disease. JAMA. 1947;133(1):33-34. doi:10.1001...
The molecular medicine perspective emphasizes cellular and molecular phenomena and interventions rather than the previous conceptual and observational focus on patients and their organs. In November, 1949, with the seminal paper, "Sickle Cell Anemia, a Molecular Disease", in Science magazine, Linus ...
about 1 in 12 African Americans carries the autosomal recessive mutation, and approximately 300,000 infants are born with sickle cell anemia annually. Thus, the aforementioned factors together are expected to increase the demand for anemia treatment and favor the growth of the studied market in the...
To evaluate the role of nutrition in Hb SS we performed anthropometric and laboratory measurements on 95 Hb SS patients and determined the effects of caloric supplementation on these parameters and on clinical course. Height and weight were both below th
Senicapoc, a small molecule inhibitor of the calcium-activated potassium channel KCa3.1, was safe and well-tolerated in clinical trials for sickle cell anemia. We previously reported proof-of-concept data suggesting that both pharmacological inhibition and genetic deletion of KCa3.1 reduces infarction ...