Sickle cell anemia--basic research reaches the clinic. N Engl J Med. 1995;332:1372-1374.Schechter , Alan N. Rodgers , Griffin P. . (1995) Sickle Cell Anemia — Basic Research Reaches the Clinic. New England Journal of Medicine 332 :20, 1372-1374 ${xml_link: 10.1056%2FNEJM...
Sickle cell anemia (SCA) is associated with a chronic proinflammatory state characterized by elevated leukocyte count, mortality from severe recurrent infections, and subsequent vasoocclusive complications with leukocyte adhesion to the endothelium and increased plasma levels of inflammatory cytokines. The ...
aIn 1949, the sickle-cell anemia of the research for a genetic one enzyme hypothesis for a further rise in a single gene a peptide 1949年,研究的镰刀细胞贫血症为一个基因一个酵素假说为进一步上升在一个唯一基因肽[translate]
Brain network hypersensitivity underlies pain crises in sickle cell disease Pangyu Joo Minkyung Kim Ying Wang ResearchOpen Access27 Mar 2024Scientific Reports Volume: 14, P: 7315 Risk factors for acute chest syndrome among children with sickle cell anemia hospitalized for vaso-occlusive crises ...
Fetal hemoglobin values with one exception were found elevated (> 2) in 89 patients with sickle-cell anemia and the mean level of Hb F was of 11.45 %. In 47 of these patients Hb F was more than 10 % by Singer's method. Hemoglobin and/or hematocrit val
Institute of Medicine Committee on Understanding Eliminating Racial Ethnic Disparities in Health Care. Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care. National Academies Press; 2002. 64. Sickle cell anemia, a race specific disease. JAMA. 1947;133(1):33-34. doi:10.1001...
The molecular medicine perspective emphasizes cellular and molecular phenomena and interventions rather than the previous conceptual and observational focus on patients and their organs. In November, 1949, with the seminal paper, "Sickle Cell Anemia, a Molecular Disease", in Science magazine, Linus ...
To evaluate the role of nutrition in Hb SS we performed anthropometric and laboratory measurements on 95 Hb SS patients and determined the effects of caloric supplementation on these parameters and on clinical course. Height and weight were both below th
Anemia was defined as a hemoglobin measure \le 12.9 g/dL among men and \le 11.9 g/dL among women [17] and then categorized into a type using the MCV measurement. If there were multiple hemoglobin measures per year the lowest was used for categorization based on World Health Organization (...
CRISPR/Cas9, a revolutionary gene-editing technology, offers new hope for treating monogenic disorders like sickle cell anemia. By precisely targeting and correcting the mutated gene responsible for the disease, CRISPR/Cas9 has the potential to provide a permanent cure, offering significant implications...