Albert Serra-Cardona and Zhiguo Zhang. Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity. Trends Biochem Sci, 43(2):136-148, February 2018.Serra-Cardona, A.; Zhang, Z. Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information ...
Asymmetry caused by replication-coupled chromatin assemblydoi:10.1038/nrg3167Darren J. BurgessNature Reviews Genetics
Our analysis of synchronized cells and asynchronously proliferating live single cells revealed a consistent order of replication-coupled destruction during both S-phase entry and DNA repair; Cdt1 is destroyed first, whereas p21 destruction is always substantially later than that of Cdt1. These ...
During DNA replication, stalled replication forks and DSBs arise when the replication fork encounters ICLs (interstrand crosslinks), covalent protein/DNA intermediates or other discontinuities in the template. Recently, homologous recombination proteins have been shown to function in replication-coupled repair...
DNA-protein crosslinks (DPCs) are caused by environmental, endogenous, and chemotherapeutic agents and pose a severe threat to genome stability. We use Xenopus egg extracts to recapitulate DPC repair in vitro and show that this process is coupled to DNA replication. A DPC on the leading strand ...
Defective replication-coupled chromatin assembly causes accumulation of recombinogenic DNA damage and checkpoint activation. 来自 figshare.com 喜欢 0 阅读量: 13 作者:M Clementeruiz,R Gonzálezprieto,F Prado 年份: 2011 收藏 引用 批量引用 报错 分享 ...
Reconstitution of the replication-coupled chromatin assembly system and recombinant H3/H4 showed that the absence of the N-terminal tails of H3 and H4 did not affect the assembly or the interaction of the histone complexes with CAF-1. Nonetheless, these experimental approaches either only partly ...
The artificial reconstitution of this genome replication system is a great challenge in in vitro synthetic biology. In this study, we attempted to construct a transcription- and translation-coupled DNA replication (TTcDR) system using circular genomic DNA encoding phi29 DNA polymerase and a ...
COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog. 2006;2:e102. [PMC free article] [PubMed] Chevalier C... AW Tai,Y Benita,LF Peng,... - 《Cell Host & Microbe》 被引量: 862发表: 2009年 Structural basis of oligomerization in the stalk re...
Metazoan cells only utilize a small subset of the potential DNA replication origins to duplicate the whole genome in each cell cycle. Origin choice is linked to cell growth, differentiation, and replication stress. Although various genetic and epigenetic