Biochemical, biomechanical and ultrastructural properties of the connective tissue matrix were investigated during the early remodeling phase of tissue repair in experimentally tenotomized and repaired rabbit Achilles tendons. Sterile surgical tenotomy was performed on the right Achilles tendons of 14 ...
We therefore conclude that the excisional reduction of a crevice to 0 mm depth was altered by gingival remodeling during the healing phase. In our experience, this remodeling took place within 3 months after surgery and clinically appeared as a limited coronal pocket closure and gain of marginal...
The Visian ICL is considered not medically necessary for adults 21 to 45 years of age to (i) correct myopia ranging from -3.0 diopters to less than or equal to -15.0 diopters with less than or equal to 2.5 diopters of astigmatism at the spectacle plane; (ii) reduce myopia ranging from ...
Alterations in ECM composition play critical roles in the regulation of the cellular responses that mediate tissue healing. In the inflammatory phase of tissue repair, clearance of dead cells and damaged tissue is accomplished by degradation of ECM proteins. This process generates bioactive ECM ...
In bone remodeling, osteoblast–osteoclast interactions are necessary and must be coordinated in time and space to maintain the focal bone remodeling balance; this balance refers to the net amount of tissue resorbed and formed at each remodeling site (i.e., focal point) to maintain the structural...
These data have since enabled phase 1/2 clinical trials of PXS-5055 in myelofibrosis (NCT04676529). PXS-5505 blocks CAF-mediated crosslinking of collagen To determine the effects of blocking lysyl oxidase family-mediated collagen crosslinking in vitro and the subsequent effects on pancreatic CCs, ...
Post-MI early response sees an increase in Ly6Chigh macrophages, whereas the later phase is dominated by predominant Ly6Clow macrophage recruitment. In this case, Ly6Chigh macrophages perform phagocytic, proteolytic, and proinflammatory functions, whereas Ly6Clow macrophages promote tissue repair by fibrob...
The faithful maintenance of DNA methylation homeostasis indispensably requires DNA methyltransferase 1 (DNMT1) in cancer progression. We previously identified DNMT1 as a potential candidate target for oral squamous cell carcinoma (OSCC). However, how the DNMT1- associated global DNA methylation is exp...
During wound healing, contractile fibroblasts called myofibroblasts regulate the formation and contraction of granulation tissue; however, pathological and... K Kis,X Liu,JS Hagood - 《Expert Reviews in Molecular Medicine》 被引量: 248发表: 2011年 Clinical applications of basic research that shows re...
Accumulating evidence demonstrates that the Wnt/β-catenin signaling pathway plays a dominant role in bone repair. However, the role of Wnt/β-catenin signaling in the remodeling phase during bone fracture healing is currently unknown. In the present stu