The healing phase is followed by the bone-remodeling phase. In this work, a mechano-regulatory cellular differentiation model was used to simulate tissue healing around an immediately loaded dental implant. All tissue types were modeled as poroelastic in the healing phase. Material properties of the...
Alterations in ECM composition play critical roles in the regulation of the cellular responses that mediate tissue healing. In the inflammatory phase of tissue repair, clearance of dead cells and damaged tissue is accomplished by degradation of ECM proteins. This process generates bioactive ECM ...
while it is being formed or is in the reversal phase from bone resorption to bone formation at other site. This implies that there is continuous focal transient loss of bone that is fully reversed in balanced remodeling; as the number of activated remodeling sites increases...
5.4 Constructive Tissue Remodeling 5.4.1 Default Mammalian Wound Healing versus Constructive Remodeling by ECM The default mammalian response to injury is highly conserved across tissue types and occurs in three overlapping yet distinct phases: the inflammatory phase, the proliferative phase, and the rem...
Here, we chose human BMSCs cultured for the 3rd passage (P3), 6th passage (P6), and 9th passage (P9), which are representative of the gradual phase of replica- tive senescence. Senescence-associated β-galactosidase (SA-β-gal) analysis showed the percentage of β-gal positive cells ...
Apoptosis may optionally provide a permanent treatment that limits or avoids inflammation and mobilization of cellular repair. Colder temperatures may be applied to induce necrosis, which may be relatively long-lasting, and/or which may incite tissue healing response that eventually restores tissue ...
tissue wound repair mechanisms that contribute to excessive deposition of ECM and contribute to AHR [44]. Finally, blood vessels are situated adjacent to large and small airways, and endothelial cells that line these vessels provide a tight barrier that facilitates blood flow to and from alveoli....
Post-MI early response sees an increase in Ly6Chighmacrophages, whereas the later phase is dominated by predominant Ly6Clowmacrophage recruitment. In this case, Ly6Chighmacrophages perform phagocytic, proteolytic, and proinflammatory functions, whereas Ly6Clowmacrophages promote tissue repair by fibroblast ...
Post-MI early response sees an increase in Ly6Chighmacrophages, whereas the later phase is dominated by predominant Ly6Clowmacrophage recruitment. In this case, Ly6Chighmacrophages perform phagocytic, proteolytic, and proinflammatory functions, whereas Ly6Clowmacrophages promote tissue repair by fibroblast ...
or characterized by a change in the ratio between generation and degeneration of cells or extracellular matrix, which leads to a change in the entire tissue manifested by: increased tissue growth, decrease tissue growth, prevention of tissue formation, enhanced tissue healing, change in the proportio...