(Fig.2a). In pre-accommodation state of the ribosome, domain III of RF1 is 60–70 Å away from the PTC, in a similar relative orientation as in the crystal forms of the free factors1,2(Supplementary Fig.4) and significantly differing from that in the post-accommodated state of the...
In bacteria, stop codons are recognized by two similar class 1 release factors, release factor 1 (RF1) and release factor 2 (RF2). Normally, during termination, the class 2 release factor 3 (RF3), a GTPase, functions downstream of peptide release where it accelerates the dissociation of ...
Translation termination in eukaryotes: polypeptide release factor eRF1 is composed of functionally and structurally distinct domains. Class-1 polypeptide chain release factors (RFs) trigger hydrolysis of peptidyl-tRNA at the ribosomal peptidyl transferase center mediated by one of the thr... LY Frolova...
Termination of translation: interplay of mRNA, rRNAs and release factors - Kisselev, Ehrenberg, et al. - 2003 () Citation Context ...sitions (7,8). The major function of eRF1 is to transfer a signal from the small to the large ribosomal subunit and to trigger peptidyl-tRNA hydrolysis ...
Class-1 polypeptide chain release factors (RFs) trigger hydrolysis of peptidyl-tRNA at the ribosomal peptidyl transferase center mediated by one of the three termination codons. In eukaryotes, apart from catalyzing the translation termination reaction, eRF1 binds to and activates another factor, eRF3...
Initiation factor elF5B catalyzes second GTP-dependent step in eukaryotic translation initiation. Initiation factors IF2 in bacteria and eIF2 in eukaryotes are GTPases that bind Met-tRNA[sup Met, sub i] to the small ribosomal subunit, eIF5B, the eukaryo... Lee,H Joon,Pestova,... - 《Pro...
Land plant genomes encode four functional ribosomal peptide chain release factors (Prf) of eubacterial origin, two (PrfA and PrfB homologs) for each endosymbiotic organelle. Formerly, we have shown that the Arabidopsis thaliana chloroplastlocalized PrfB homolog, PrfB1, is required not only for termina...
The key factors that facilitated the smooth implementation by SIAP of all planned activities for 2009 were: (a) the strong [...] daccess-ods.un.org 推动亚太统计所按计划顺利实施 2009 年各项活动的主要因素是:(a) 东道国日 本政府的有力支持,继续提供主要现金捐助、行政和基础设施方面的援助,...
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The factors required for cap-dependent and HCV IRES-dependent in vitro translation were prepared basically as described previously (Machida et al., 2014, 2018), except that the following factors were produced as described below. The five subunits of human eIF2B were co-expressed in FreeStyle 293...