Mutations in the NF-κB signaling pathway: implications for human disease. Oncogene 2006; 25: 6831–6843. 11 Grumont RJ, Gerondakis S. The subunit composition of NF-κB complexes changes during B-cell development. Cell Growth Differ 1994; 5: 1321–1331. 12 Liou HC, Sha WC, Scott ML, ...
nucleus. Is expressed in axial skeleton; eye; heart; and ureter. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, ...
Macroautophagy can regulate cell signalling and tumorigenesis via elusive molecular mechanisms. We establish a RAS mutant cancer cell model where the autophagy gene ATG5 is dispensable in A549 cells in vitro, yet promotes tumorigenesis in mice. ATG5 repr
The chaperon heat shock protein 90 (HSP90) constitutes an important target for anti-tumor therapy due to its essential role in the stabilization of oncogenes. However, HSP90 is ubiquitously active to orchestrate protein turnover, chemotherapeutics that t
Anomaly Detection and Artificial Intelligence Identified the Pathogenic Role of Apoptosis and RELB Proto-Oncogene, NF-kB Subunit in Diffuse Large B-Cell LymphomaBackground: Diffuse large B-cell lymphoma (DLBCL) is one of the most frequent lymphomas. DLBCL is phenotypically, genetically, and ...
RELB RELB proto-oncogene, NF-kB subunit [ Homo sapiens (human). Available online: https://www.ncbi.nlm.nih.gov/gene/5971 (accessed on 18 May 2021). Bren, G.D.; Solan, N.J.; Miyoshi, H.; Pennington, K.N.; Pobst, L.J.; Paya, C.V. Transcription of the RelB gene is regul...
The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus. Proc Natl Acad Sci U S A. 1993 Feb 1; 90 (3):1023–1027.Doerre S, Sista P, Sun SC, Ballard DW, Greene WC. The c-rel ...
1992. The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon- gamma gene at a site related to an interferon- stimulable response element. Proc. Natl. Acad. Sci. USA 89: 1740-1744....
Genomic organization and expression of the rearranged REL proto-oncogene in the human B-cell lymphoma cell line RC-K8. Genes Chromosomes Cancer 2002, 34, 129-135. [CrossRef] [PubMed]Kalaitzidis D, Gilmore TD. Genomic organization and expression of the rearranged REL proto-oncogene in the ...
MALT1 directs B cell receptor–induced canonical nuclear factor-B signaling selectively to the c-Rel subunitAnimalsMiceMembrane MicrodomainsAdaptor Proteins, Signal TransducingCaspasesNF-kappa BProto-Oncogene Proteins c-relReceptors, Antigen, B-Cell...