The relaxin signaling pathway is widely present in the body. We use the cardiovascular effect as an example to describe the way in which the relaxin signaling pathway works: the distribution and function of relaxin and its receptor RXFP1 are found in the cardiovascular system with an important ...
RelaxinGastrointestinalmotilitySmoothmuscleAC/cAMPGC/cGMPAIM To investigate the signaling pathways involved in the relaxin(RLX) effects on ileal preparations from mice through mechanical and electrophysiological experiments.METHODS For mechanical experiments, ileal preparations from female mice were mounted in or...
Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2 The hormone relaxin inhibits renal myofibroblast differentiation by interfering with TGF-beta1/Smad2 signaling. However, the pathways involved in the relax... I Mookerjee,TD Hewitson,ML Halls,... - ...
Supported byUniversity of Florence (ex 60%) ROBERTASQUECCORICATEN15 (to Squecco R). Institutional animal care and use committee statement: The experimental protocol was designed in compliance with the guidelines of the European Communities Council Directive 2010/63/UE and the recommendations for the...
AIM To investigate the signaling pathways involved in the relaxin(RLX) effects on ileal preparations from mice through mechanical and electrophysiological experiments.METHODS For mechanical experiments, ileal preparations from female mice were mounted in organ baths containing Krebs-Henseleit solution. The ...
International Journal of Molecular Sciences Article Relaxin 2/RXFP1 Signaling Induces Cell Invasion via the β-Catenin Pathway in Endometrial Cancer Misaki Fue 1, Yasuhiro Miki 1,* ID , Kiyoshi Takagi 2, Chiaki Hashimoto 3, Nobuo Yaegashi 3, Takashi Suzuki 2 and Kiyoshi Ito 1 1 Department of...