NUCLEIC ACIDS/metabolismPROTEINS/metabolismPSEUDOMONAS/metabolismPYRIMIDINES/pharmacologyThe ratio of Δ protein/Δ nucleic acid has been studied in exponentially growing cultures of Pseudomonas azotogensis. In
In the nucleus, biological processes are driven by proteins that diffuse through and bind to a meshwork of nucleic acid polymers. To better understand this interplay, we present an imaging platform to simultaneously visualize single protein dynamics toge
Cardiovascular disease (CVD) represents the most significant cause of death in postmenopausal women. Advanced glycation end products (AGEs) are formed by nonenzymatic modification of proteins, lipids, and nucleic acids by glucose. This review focuses on the contribution of AGEs and their receptors to...
Foci of Polycomb group proteins in the nucleus that are involved in both genome organization and repression of gene expression. Molecular condensates Non-membrane-bound subcompartments in the nucleoplasm or cytoplasm that are strongly enriched in or depleted of specific proteins or nucleic acids. Rights...
(GLP) compliant animal toxicity studies, which generally are not performed until the compound development phase. Thetoxicity assessmentof biological molecules (i.e. large molecules such as proteins) in the preclinical stage has a different nature than small molecules since there generally are...
RING finger domains from a number of proteins have been shown to function as E3 ubiquitin ligases wherein they mediate protein-protein interactions with E2 ubiquitin ligases [11]. Besides the well acknowledged role of RING fingers in the ubiquitination pathway, the B-box and the Zf-UBP are ...
ConSurf 2010: Calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Res. 2010, 38, W529–W533. [CrossRef] [PubMed] Nutrients 2015, 7 6247 44. Lo, A.; Cheng, C.-W.; Chiu, Y.-Y.; Sung, T.-Y.; Hsu, W....
The observed cellular pathology was consistent with nuclear upregulation of associated DDR proteins, particularly those involved in base excision repair and DSB repair pathways. Conclusions Collectively our study demonstrates the accumulation of seed-competent pathological nuclear associated aSyn, alongside ...
Nevertheless, they provide evidence that functionally important sequence motifs may be evolutionarily conserved from ancient to more modern cell signaling proteins and stimulate investigations on their potential into biotechnological and finalized perspectives. View chapter Book 2016, Lessons in ImmunityAdriana ...
Androgen binds to the AR, leading to conformational change of AR, dissociation of heat shock proteins, driving the interaction between the N- and C-terminus of AR, and importin-α binds AR to transport AR into the nucleus22. In the nucleus, the AR dimerizes and binds to androgen response ...