The importance of sodium ions in this system was shown to be exercised on the entry of the amino acids into the nucleus rather than in any of the more immediate reactions in the process of protein synthesis Proteins are synthesized in association......
et al. CDD: conserved domains and protein three-dimensional structure. Nucleic Acids Res. 41, D348–D352 (2013). CAS PubMed Google Scholar Sander, C. & Schneider, R. Database of homology-derived protein structures and the structural meaning of sequence alignment. Proteins 9, 56–68 (...
- 《Nucleic Acids Research》 被引量: 34发表: 1995年 On the relationship between conformation and stability in solid pharmaceutical protein formulations Long-term stability is critical in the successful development of pharmaceuticals, including macromolecular ones, such as proteins. Due to the relative ...
Although Garrod and several other scientists had demonstrated a clear association between genes (which were known to be on chromosomes in the nucleus) and proteins, the precise nature of this link remained mysterious for some time. Researchers wondered whether chromosomes participated directly in protein...
The biological function of proteins and nucleic acids relies on their complex structures, yet dynamics provides an additional layer of functional adaptability. Numerous studies have demonstrated that RNA is only able to perform the multitude of functions for which it is responsible by readily changing ...
Using our quantitative time-resolved inventory of RNA and protein, we have developed a picture of the overall strategies used by the egg and embryo. We also provide a deep dataset of individual stories of proteins and RNA that can now be woven, by us and others, into narratives that can ...
However, it is surprising to see that such useful technique has only very limited applications to biomacromolecules, albeit the solved 3D atom-resolution structures of proteins, nucleic acids and their complexes have accumulated rapidly in past decades. Here, we present a proof-of-concept paradigm ...
Results indicate that approximately 50% of the intracellular /sup 67/Ga is incorporated in the cellular residual material formed mainly by phospholipids, proteins, and nucleic acids. The relationship between both /sup 67/Ga and /sup 45/Ca incorporations is discussed. (auth)...
In the nucleus, biological processes are driven by proteins that diffuse through and bind to a meshwork of nucleic acid polymers. To better understand this interplay, we present an imaging platform to simultaneously visualize single protein dynamics toge
Foci of Polycomb group proteins in the nucleus that are involved in both genome organization and repression of gene expression. Molecular condensates Non-membrane-bound subcompartments in the nucleoplasm or cytoplasm that are strongly enriched in or depleted of specific proteins or nucleic acids. Rights...