Many studies of text mining attempted to identify the relationship between gene and disease by mining the literature, but they did not consider the biological events in which genes show abnormal behaviour in response to diseases. In this study, we propose to identify disease-related genes that ...
In this article, we used the human protein–protein interactions (PPIs), disease genes with their classifications and embryo development genes and reconstructed a human disease-embryo development network to investigate the relationship between disease genes and embryo development genes. We found that ...
The relationship between exercise and cancer has long both intrigued and puzzled oncologists and exercise physiologists.Exercise is strongly associated with lowered risks for many types of cancer. In epidemiological studies, people who regularly exercise generally prove to be much less likely to develop...
The relationship between exercise and cancer has long both intrigued and puzzled oncologists and exercise physiologists. Exercise is strongly associated with lowered risks for many types of cancer. At the same time, exercise involves biological stress, which typically leads to a short-term increase in...
There is a growing body of evidence to support the involvement of proinflammatory cytokines in the pathophysiology of depression; however, no previous studies have examined the relationship between cytokines and the brain morphology of patients with major depressive disorder (MDD). We therefore evaluated...
Understanding the links between genetic, epigenetic and non-genetic factors throughout the lifespan and across generations and their role in disease susceptibility and disease progression offer entirely new avenues and solutions to major problems in our society. To overcome the numerous challenges, we ...
The MR analysis demonstrated a causal relationship between DR and PD (odds ratio [OR]=0.86; 95% confidence interval [CI] 0.79–0.93;p=3.24E04), in which DR acted as a protective factor against PD. There were 81 DEGs identified from the PD and DR datasets, of which 29 genes had ...
Here, we examine the molecular events in CRC, with particular focus on the interaction between genes and environment, and review the most current research in this area. 展开 关键词: Environment Colorectal Cancer environmental factors Diet overview 环境 膳食 ...
Heavey, P. M., McKenna, D., and Rowland, I. R. 2004. Colorectal cancer and the relationship between genes and the environment. Nutr. Cancer 48: 124–141. View ArticleHeavey PM, McKenna D, Rowland IR. Colorectal cancer and the relationship between genes and the environment. Nutr Cancer....
Furthermore, genetic variants are assigned prior to disease start, so the genotype is not influenced by the condition, reducing reverse causality14. Methods Mendelian randomization data and process To investigate the causal link between PD and cardio-cerebrovascular diseases, we used a two-sample MR...