Garrod's proposition, attributing a defective enzyme to a defective gene, was the first ever to suggest a direct link betweengenesand proteins. Given that thenucleuswas known to house thegenetic material, which had already been identified asdeoxyribonucleic acid(DNA), several investigators subsequently...
Discover the function of chromatin. See what chromatin looks like and where in a cell it is located. Explore chromatin’s function in many cell processes. Related to this Question What is the relationship between DNA and proteins? How are chromatin, chromosomes, and DNA related?
Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome characterized by exceedingly short telomeres and mutations in telomere biology genes. To understand the interaction between methylation and TL in humans, we measured LINE-1, pericentromeric (NBL2), and subtelomeric (D4Z4) ...
Nucleotides are the building blocks of a DNA strand. As such, they are the monomers that make polynucleotide chains to form the DNA. To form the polynucleotide chain, a bond is formed between the 3' carbon of the pentose of one nucleotide and the phosphate attached to the 5' (5th) ...
A large complex of proteins, including RNA polymerase II and its associated general transcription factors, which is necessary for the transcription of protein-coding genes. TATA box Named after its conserved DNA sequence, the TATA box is a non-coding DNA sequence found in many eukaryotic core pro...
Megakaryocytes are a distinct population of bone marrow cells that have the unique feature of increasing their DNA content without undergoing division. The biological effect of ploidy distribution on gene expression, receptor expression and protein synthesis is still unknown. Using molecular hybridization ...
Our study aimed to investigate the association between polymorphism of three core genes belonging to NER pathway and preeclampsia (PE) risk in Chinese Han Women. The DNA used in our experiment was extracted from 1004 cases and 1274 normal pregnant women. All single nucleotide polymorphisms (SNPs)...
But the process that translates genes into proteins turned out to be much more involved than anticipated. Other elements—proteins, snippets of RNA, regions of the genome that act as binding sites, and chemical groups that attach to DNA—also regulate protein production, complicating the relationsh...
[Relationship between the duration of the period of DNA synthesis and the rate of movement of the replication fork in cultures of human and mammalian cells] [Relationship between the duration of the period of DNA synthesis and the rate of movement of the replication fork in cultures of human ...
Genetic evidence suggests glioma risk is altered by leukocyte telomere length, allergic disease (asthma, hay fever or eczema), alcohol consumption, childhood obesity, low-density lipoprotein cholesterol (LDLc) and triglyceride levels. DNA methylation (DN