Our findings highlight the critical role of the unique structure of the RHD for the survival of p50 during proteosomal processing.doi:10.1074/jbc.M304140200Lin, L.Kobayashi, M.J Biol ChemJournal of Biological C
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in...
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in...
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in...
The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation dom
这些成员均有一个约300个氨基酸的Rel同源结构域(Relhomology domain,RHD)。这个高度保守的结构域介导Rel蛋白形成同源或异源二聚体,该结构域也是NF-κB与靶基因DNA序列的特异性结合区域。细胞内NF-κB的活化过程受到精细调控。 通常情况下,在细胞质中的NF-κB处于失活状态,与抑制蛋白IkB(inhibitoryprotein of NF-kB...
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These proteins share a structurally conserved N-terminal region termed the Rel homology domain (RHD). The RHD mediates dimerization, DNA binding, nuclear localisation and interaction with the inhibitors of kappa B (IκB) proteins. In the active form, NF-κB consists of heterogeneous dimers of ...
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in...
Background: c-Rel c-Rel/Rel, the cellular counterpart of the v-Rel oncogene of the avian reticuloendotheliosis retrovirus, is a 85 kDa class II member of the Rel/NK-kappa B family of transcription factors. All Rel family members contain a RHD (Rel homology domain) that is involved in ...