The Rel homology domain (RHD) is an evolutionarily conserved domain found in some eukaryotic transcription factors, including NF│蔅, the nuclear factors of activated Tヽells (NFATs) and the...Springer Berlin HeidelbergEncyclopedia of Molecular Pharmacology...
作者: SB Heidelberg 摘要: The Rel homology domain (RHD) is an evolutionarily conserved domain found in some eukaryotic transcription factors, including NF‐κB, the nuclear factors of activated T‐cells (NFATs) and the drosophila 被引量: 1 年份: 2008 收藏...
迄今为止,在哺乳动物细胞内共发现5种NF-κB/Rel家族成员,它们分别是RelA(即p65)、RelB、C-Rel、p50/NF-κB1(即p50/RelA)和p52/NF-κB2。 这些成员均有一个约300个氨基酸的Rel同源结构域(Relhomology domain,RHD)。这个高度保守的结构域介导Rel蛋白形成同源或异源二聚体,该结构域也是NF-κB与靶基因DNA序列...
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in...
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in...
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This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in...
We show that the association of p50 with a mutant Rel-homology domain (RHD) defective for DNA binding led to synergistic activation of kappaB site-dependent transcription, whereas neither protein alone had any effect. Partial proteolytic analysis showed that the conformation of p50 in these ...
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in...
背景资料 The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene.This gene is mapped to chromosome 2p13-p12.The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-ter...