Regulator of G protein signaling 6 (RGS6) is a member of a family of proteins called RGS proteins, which function as GTPase-activating proteins (GAPs) for G卤 subunits. Given the role of RGS6 as a G protein GAP, the link between G protein activation and cancer, and a reduction of ...
We also demonstrated that RGS6 functions as a critical negative regulator of SNc D 2 autoreceptor signaling allowing for proper modulation of DA-dependent motor behaviors. Given that β-agonists repress α-synuclein expression through their activation of β2-adrenorecetor-Gα s , a GPCR that ...
Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. FASEB J. 2014;28(4):1735–44. CentralStewart, A. et al. Regulator of G-protein signaling 6 (RGS6) promotes anxiety and ...
Here, we identify regulator of G protein signaling 6 (RGS6), up-regulated in the livers of NAFLD patients, as a critical mediator of hepatic steatosis, fibrosis, inflammation, and cell death. Human patients with high hepatic RGS6 expression exhibited a corresponding high inflammatory burden, ...
Pharmacology Regulator of G protein signaling 6 (RGS6a multifarious and pleiotropic modulator of G protein coupled receptor signaling in brain THE UNIVERSITY ... AM Stewart - Dissertations & Theses - Gradworks 被引量: 0发表: 2014年 Multifarious molecular signaling cascades of cardiac hypertrophy: can...
Regulator of G Protein Signaling 6 (RGS6), a Novel Suppressor of Bladder Carcinogenesis 喜欢 0 阅读量: 26 作者:J Yang,L Platt,B Maity,Stella㏑ita Ibeawuchi,R Fisher 摘要: Urinary bladder cancer, the fifth most common cancer in the United States, is largely caused by exposure to toxic ...
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纯化方法Protein A purified 目标详细情况 别名RGS13 背景RGS13 encodes a protein which is a member of the regulator of G protein signaling (RGS) family. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively...
Migration of plasma cells to the bone marrow is critical factor to humoral immunity and controlled by chemokines. Regulator of G protein signaling 1 (RGS1) is a GTPase-activating protein that controls various crucial functions such as migration. Here, we show that RGS1 controls the chemotactic ...
摘要: •GATA-6 is highly expressed in colonic smooth muscle cells.•RGS4 is a novel target for GATA-6 transcription factor.•GATA-a response element is essential to regulate the core promoter of RGS4.•GATA-6 regulates IL-1β-induced RGS4 upregulation....