Huang ZL, Urade Y, Hayaishi O (2007) Prostaglandins and adenosine in the regulation of sleep and wakefulness. Curr Opin Pharmacol 7(1):33–38Huang ZL , Urade Y , Hayaishi O ( 2007 ): Prostaglandins and adenosine in the regulation of sleep and wakefulness . Curr Opin Pharmacol 7 : 33...
Next, we describe the main modulatory drives of sleep and wakefulness, including homeostatic, circadian, and motivational processes. Finally, we describe a revised integrative model for sleep/wake regulation. This is a preview of subscription content, access via your institution Access options ...
Humans have been fascinated by sleep for millennia. After almost a century of scientific interrogation, significant progress has been made in understanding the neuronal regulation and functions of sleep. The application of new methods in neuroscience tha
REM sleep is associated with distinct global cortical dynamics and controlled by occipital cortex Article Open access 12 November 2022 Neuro-orchestration of sleep and wakefulness Article 29 December 2022 Prefrontal cortical regulation of REM sleep Article 21 September 2023 Data...
M Kayabekir - 《Sleep Medicine & the Evolution of Contemporary Sleep Pharmacotherapy Working Title》 被引量: 0发表: 2021年 The role of histaminergic system of the brain in the regulation of sleep-wakefulness cycle The structure and the morphological and neurochemical connections of the histaminergic...
Prostaglandins and adenosine in the regulation of sleep and wakefulness and adenosine are potent humoral sleep-inducing factors that accumulate in the brain during prolonged wakefulness. PGD is produced in the brain by lipocali... ZL Huang,Y Urade,O Hayaishi - 《Current Opinion in Pharmacology》 ...
The extracellular concentration of adenosine increases in the brain during prolonged wakefulness and decreases during the sleep recovery period. Therefore, adenosine is proposed to act as one of homeostatic regulators of sleep. There are four adenosine receptor subtypes, adenosine A1 receptor (A1R), A2...
Sleep and wakefulness control in the mammalian brain requires the coordination of various discrete interconnected neurons. According to the most conventional sleep model, wake-promoting neurons (WPNs) and sleep-promoting neurons (SPNs) compete for network dominance, creating a systematic "switch" that ...
and Mindful Awareness Research Center, University of California, Los Angeles, CA, USA; 2Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA Sleep disturbances including insomnia independently contribute to risk of inflammatory disorders and major depressive disorder....
Recent molecular studies suggest the nucleus suprachiasmaticus as a wake-promotin area of the brain. The most important endogenously accumulated metabolite during wakefulness that initiates sleep is adenosine. Beside adenosine, the sleep-initiating factors are also GABA, glycine, PGD2, and cytokines ...