Taking this into consideration, we took a multifaceted approach to investigate the mechanisms by which individuals avoid negative affective symptoms associated with prolonged alcohol abstinence, one of the leading causes of relapse. Using a mouse model of chronic alcohol consumptio...
However, AEC-associated claudins did not simply decrease in response to alcohol. Instead, claudin-5 was significantly increased in alcohol-exposed AECs as compared with control AECs (Fig. 1d,e), consistent with previous analysis of freshly isolated type II cells and AECs cultured on tissue ...
BACKGROUND/AIMS: Expression of , the gene encoding the iron regulatory hepcidin, is inappropriately low in -associated and knockout ((-/-)). Since chronic alcohol consumption is also associated with disturbances in iron metabolism, we investigated the effects of alcohol consumption on hepcidin expre...
Response to: 'Alcohol, sex and AIDS' tobacco, alcohol and the environmenttobacco smoking among womentobacco exposure in pregnancy ‐ and rate of adverse outcomes, preterm birth or fetal growth ... R Pillai,RR Watson - 《Alcohol & Alcoholism》 被引量: 5发表: 1990年 加载更多来源...
You might find these chapters and articles relevant to this topic. A conceptual model of ego depletion and alcohol-related aggression Brynn E.Sheehan,CathyLau-Barraco, inAggression and Violent Behavior, 2016 2.2Self-regulation As previously mentioned,self-regulationrefers to the state level of regula...
Understanding the neural mechanisms underlying individual drinking behaviors is of critical importance to the alcohol addiction field. Thus, to parse out individual differences in alcohol drinking behaviors and to probe the VTA dopaminergic reward circuit, we used a continuous access, two-bottle choice ...
Glucose as a favorite carbon source exerts dominant regulatory effects on yeast cell metabolism via several signaling pathways. They act in concert to fine-tune glucose transport, metabolism, and transcriptional machineries in response to altering exogen
werecombinedto createanewtreatmentsupplementcalledaffectregulationtraining(ART),whichcouldbeaddedtoenhance cognitive–behavioraltherapy(CBT)foralcoholdependence.Adrafttherapymanualwasgiventotherapists andtreatmentexpertsbeforebeingadministeredtoseveralpatientswhoalsoprovidedinput.Aftertwo roundsofmanualdevelopment(stage1a),...
For long-term alcohol administration, C57BL/6 mice (10 weeks old) were aseptically implanted with gastrostomy catheters as previously described.16, 17 An increasing dose of ethanol (22.7 to 35 g/kg per day) or control solutions was infused for 4 weeks. All animal experiments were performed ...
However, during insulin resistance (IR), when insulin signalling is blunted and accompanied by hyperinsulinaemia, the promotion of hepatic DNL continues unabated and hepatic steatosis increases. Here, we show that WD40 repeat-containing protein 6 (WDR6) promotes hepatic DNL during IR. ...