No ligand for RPTPα is known, although the glycosylphosphatidylinositol-linked protein contactin has been shown to form a complex with RPTPα in neuronal cells (43), and recent studies have suggested that newborn calf serum may contain ligands for the phosphatase (44). The existence of non-...
Proliferating tumor cells require continuous protein synthesis. De novo synthesis of most proteins is regulated through cap-dependent translation. Cellular stress such as ionizing radiation (IR) blocks cap-dependent translation resulting in shut-down of
The rapid and selective regulation of a target protein within living cells that contain closely related family members is an outstanding challenge. Here we introduce genetically directed bioorthogonal ligand tethering (BOLT) and demonstrate selective inh
It is well known that protein glycosylation plays a critical role in the regulation of protein structure22, signal transduction23, cell-cell and cell-environment interactions24,25,26, immune responses27,28, hormone action29, cancer progression30and embryonic development31,32. In the glycosylation pro...
CCN proteins are multimodular proteins consisting of four distinct structural domains or modules, except for CCN5, which lacks the carboxyl-terminal fourth domain. Following an N-terminal signal peptide for secretion, the four domains are an insulin-like growth factor binding protein (IGFBP) ...
MicroRNAs (miRNAs) are small non-coding RNA transcripts that affect various cellular pathways by serving as regulators of gene expression at the translational and transcriptional level. Nuclear receptors (NRs) are ligand-activated transcription factors t
comprehensively, we performed a PPI assay using Protein Active Array® (CellFree Sciences, Matsuyama, Japan) containing 19,676 recombinant human proteins as GST-fused proteins generated by wheat germ cell-free protein synthesis [19] for interaction with biotinylated S100A2 as a protein ligand (...
This review covers the physiological aspects of regulation of the arabinose operon in Escherichia coli and the physical and regulatory properties of the operon's controlling gene, araC. It also describes the light switch mechanism as an explanation for many of the protein's properties. Although many...
the Interaction of Type I IFNs with the ReceptorThe Type II IFN (IFN-γ) Receptor Chromosomal Localization of the IFN-γ Receptor Ligand-binding Chain ... Sidney Pestka M.D. Chairman and Professor Chief Scientific Officer,CD Krause - Wiley‐VCH Verlag GmbH & Co. KGaA 被引量: 4发表: 20...
J. The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. J. Biol. Chem. 277, 18346–18356 (2002). CAS PubMed Google Scholar Oikawa, D., Kimata, Y., Kohno, K. & Iwawaki, T. Activation of...