Proliferating tumor cells require continuous protein synthesis. De novo synthesis of most proteins is regulated through cap-dependent translation. Cellular stress such as ionizing radiation (IR) blocks cap-dependent translation resulting in shut-down of
No ligand for RPTPα is known, although the glycosylphosphatidylinositol-linked protein contactin has been shown to form a complex with RPTPα in neuronal cells (43), and recent studies have suggested that newborn calf serum may contain ligands for the phosphatase (44). The existence of non-...
In this respect, Kaasbøll et al. reported that CCN2 is secreted as an inactive prepropeptide that requires proteolytic processing in order to release the bioactive ligand. Indeed, similar fragments of CCN1 and CCN3 were also fully active biological entities. Furthermore, Kaasbøll et al. s...
The rapid and selective regulation of a target protein within living cells that contain closely related family members is an outstanding challenge. Here we introduce genetically directed bioorthogonal ligand tethering (BOLT) and demonstrate selective inh
J. The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. J. Biol. Chem. 277, 18346–18356 (2002). CAS PubMed Google Scholar Oikawa, D., Kimata, Y., Kohno, K. & Iwawaki, T. Activation of...
Signal termination: GRK, arrestin, and G protein switching Termination of GPCR signaling is mediated by multiple mechanisms. Signaling at the receptor can be terminated by degrading the ligand, as is the case for most peptide agonists, or by removing the ligand from the vicinity of the receptor...
The mechanism underlying homeostatic regulation of the plasma levels of free retinol-binding protein and free thyroxine, the systemic distribution of which is of great importance, has been investigated. A simple method has been developed to determine the rate of dissociation of a ligand from the bin...
Thus, there is still a lack of effective target drugs for the Hippo/YAP axis in human cancer. Based on this, we shifted our strategy to inhibiting the upstream membrane receptors of the Hippo/YAP axis in gastric cancer. In the current study, we identified a novel G-coupled protein ...
Reversible catalysis regulation has gained much attention and traditional strategies utilized reversible ligand coordination for switching catalyst’s conformations. However, it remains challenging to regulate the catalytic activity of metal nanoparticle-based catalysts. Herein, we report a new DNA nanomachine...
The Raf Kinase Inhibitor Protein (RKIP) is a unique gene product that directly inhibits the Raf/Mek/Erk and NF-kB pathways in cancer cells and resulting in the inhibition of cell proliferation, viability, EMT, and metastasis. Additionally, RKIP is involved in the regulation of cancer cell resi...