Reversible catalysis regulation has gained much attention and traditional strategies utilized reversible ligand coordination for switching catalyst’s conformations. However, it remains challenging to regulate the catalytic activity of metal nanoparticle-based catalysts. Herein, we report a new DNA nanomachine...
Our results demonstrate that regulation of the affinity of RNA-binding proteins (RBPs) to export receptors along with the weak interaction between the nuclear basket protein (Mlp1 or Tpr) and RBPs are the minimum requirements to distinguish and retain aberrant mRNAs. Our results show that the ...
Proliferating tumor cells require continuous protein synthesis. De novo synthesis of most proteins is regulated through cap-dependent translation. Cellular stress such as ionizing radiation (IR) blocks cap-dependent translation resulting in shut-down of
Protein kinase C (PKC) has also been shown to cause a synergistic increase in ligand-induced CYP1A1 gene induction (Chen and Tukey, 1996) and has also been shown to be activated by AhR ligand (Hann...Park, S., Henry, E.C., and Gasiewicz, T.A. (2000). Regulation of DNA ...
Following ligand binding, events are triggered inside the cell. “Outside-in signaling” events include changes in cell shape, integrin localization, intracellular pH, induction of protein phosphorylation, and gene transcription (1). The cytoplasmic sequences of the integrins appear to be involved in...
The specific binding of the amyloid precursor protein (APP) to glycosaminoglycans (GAG) suggests that APP is a cell adhesion molecule (CAM) and/or substrate adhesion molecule (SAM). In order to characterize this activity of APP in the brain at the molecular level, we have purified and charact...
Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites Betaglycan, also known as the TGF-beta type III receptor, is a membrane-anchored proteoglycan that presents TGF-beta to the type II signaling receptor, a t.....
These changes of the redox milieu are perceived by specific receptor molecules on the cell surface and play a role in cell-cell communication. Indeed, a cell can respond simultaneously to different signals by ligand binding and activation of specific signaling cascades. Rapid and specific reactions ...
Microdetermination of phosphorus. Anal. Chem. 28, 1756–1758 (1956). Article CAS Google Scholar Allison, T. M. et al. Quantifying the stabilizing effects of protein-ligand interactions in the gas phase. Nat. Commun. 6, 8551 (2015); https://doi.org/10.1038/ncomms9551 Marklund, E. G....
In the resting state, the G protein forms a heterotrimer, consisting of a guanosine diphosphate (GDP)-bound form of Gα (Gα-GDP) and Gβγ. Ligand binding to GPCRs induces conformational changes of Gα-GDP, promoting the dissociation of GDP. Guanosine triphosphate (GTP) spontaneously ...