Reversible catalysis regulation has gained much attention and traditional strategies utilized reversible ligand coordination for switching catalyst’s conformations. However, it remains challenging to regulate
( 1994) Studies of the amyloid precursor protein (APP) in brain : regulation of APP-ligand binding, in Amyloid Precur- sor- in Development, Aging and Ahbeimer's Disease (Masters C. L ., Beyreuther K ., Trillet M ., and Christen Y ., eds), pp . 76- 89 . Springer, Berlin /...
Helical propensity in an intrinsically disordered protein accelerates ligand binding. Angew. Chem. Int. Ed. Engl. (2014). Schafmeister, C. E., Po, J. & Verdine, G. L. An all-hydrocarbon cross-linking system for enhancing the helicity and metabolic stability of peptides. J. Am. Chem. ...
2A) and without bound phorbol ester by Hurley and co-workers(15), as was the NMR structure of the corresponding repeat from protein kinase C α, in the absence of ligand(16). Strikingly, this β sheet-rich domain undergoes no conformational change upon ligand binding. Rather, binding of ...
Receptor down-regulation refers to the physiological process of decreasing the concentration and affinity of receptors through ligand-receptor binding and activation. This regulation can occur on a short-term basis, taking seconds to minutes, or on a long-term basis, taking hours to days. Mechanisms...
Proliferating tumor cells require continuous protein synthesis. De novo synthesis of most proteins is regulated through cap-dependent translation. Cellular stress such as ionizing radiation (IR) blocks cap-dependent translation resulting in shut-down of
inside the molecule, although the PK enzyme activity is low, it has protein activation activity [60]. In Fig.3b we specifically list the each participating allosteric regulates the binding site of the small molecule and the binding site of the activator in the PKM2 protein spatial structure [...
protein expression and PTMs. However, because of the numerous cell activities that are directly governed by proteins, there is no doubt that the regulation of protein components in hPSCs should have profound influences on cellular pluripotency and differentiation capacity. The consequences of altering ...
Our results demonstrate that regulation of the affinity of RNA-binding proteins (RBPs) to export receptors along with the weak interaction between the nuclear basket protein (Mlp1 or Tpr) and RBPs are the minimum requirements to distinguish and retain aberrant mRNAs. Our results show that the ...
We describe the use of PI3Kβ protein and/or its encoding gene for the screening for substances useful in the treatment of cancers, preferably breast cancers, as well as a method for