Cell Adhesion Molecules组织白细胞细胞粘着分子Surgical wounds within previously irradiated tissues are subject to an increased incidence of postoperative complications including microvascular occlusion and impaired wound healing. The high radiation sensitivity of the vasculature has previously mainly been linked ...
Springer, T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.Cell76, 301–314 (1994). ArticleCASPubMedGoogle Scholar McEver, R.P. Selectins: lectins that initiate cell adhesion under flow.Curr. Opin. Cell Biol.14, 581–586 (2002). ...
Inflammation is a key pathological feature of many diseases, disrupting normal tissue structure and resulting in irreversible damage. Despite the need for effective inflammation control, current treatments, including stem cell therapies, remain insuffici
Cell 112, 645–657 (2003). Using the Cre– loxP system with Cre expression under control of the lysozyme M promoter, the authors showed that HIF1α deficiency in macrophages causes metabolic defects as a consequence of inhibited glycolysis and results in an impaired inflammatory response. CAS ...
Vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin are inducible proteins involved in cell-cell adhesion. Immunohistochemical studies have indicated that human atherosclerotic plaques contain smooth muscle cells (SMCs) that express ICAM-1 and VCAM-...
(2011). Labile disulfide bonds are common at the leukocyte cell surface. Open Biol 1: 110010, https://doi.org/10.1098/rsob.110010.Search in Google Scholar Moore, T.I., Aaron, J., Chew, T.L., and Springer, T.A. (2018). Measuring integrin conformational change on the cell surface ...
Leukocyte recruitment plays a major role in the immune response to infectious pathogens and during inflammatory and autoimmune disorders. The process of leukocyte extravasation from the blood into the inflamed tissue requires a complex cascade of adhesive events between the leukocytes and the endothelium ...
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The immune-inflammatory response is associated with increased nitro-oxidative stress. The aim of this mechanistic review is to examine: (a) the role of redox-sensitive transcription factors and enzymes, ROS/RNS production, and the activity of cellular an
Excessive levels of the glycolysis metabolite methylglyoxal (MG) elicit enhanced expression of adhesion molecules which foster leukocyte–endothelial cell interactions. The signaling mechanisms involved remain elusive. To address this, we investigated the signal transduction of leukocyte- and endothelial-express...