Cell Adhesion Molecules组织白细胞细胞粘着分子Surgical wounds within previously irradiated tissues are subject to an increased incidence of postoperative complications including microvascular occlusion and impaired wound healing. The high radiation sensitivity of the vasculature has previously mainly been linked ...
L-selectin (leukocyte adhesion molecule 1/MEL-14), a member of the selectin family of cell adhesion molecules, mediates leukocyte rolling and leukocyte adhesion to endothelium at sites of inflammation. In addition, L-selectin mediates the binding of lymphocytes to high endothelial venules (HEV) of...
To elucidate this process, the present work analyzes the kinetics of the expression of intercellular adhesion molecule-1 (ICAM-1) and the accumulation of inflammatory leukocyte function antigen-1 (LFA-1)-positive cells in relation to the appearance of hepatocellular necrosis in the model of acute ...
The cytoskeleton consists of three main components: microfilaments, microtubules and IFs. Monomeric G-actin molecules polymerize into actin filaments (F-actin), which are dynamically involved in numerous cellular processes throughout a cell’s lifespan. They interact with a diverse array of actin-bin...
cell proliferation and differentiation, induce cell cycle arrest, and reduce IL-2 production to exert the inhibitory function in T cell modulation [67]. CTLA-4 has been reported to mediate negative regulation of T cell responses through several ways, such as attenuating the T cell receptor (TCR...
Interestingly, several lines of evidence support a pathogenic role of sEng in the vascular system, including endothelial dysfunction, antiangiogenic activity, increased vascular permeability, inflammation-associated leukocyte adhesion and transmigration, and hypertension [18,22,23,24,25,26,27]. Because of...
In addition to structural abnormalities, tumor vasculature is also characterized by altered EC adhesiveness. Tumor ECs undergo genetic alteration, often with downregulated adhesion proteins, such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) that are neces...
Leptin increased intracellular oxidative stress in a leptin receptor (OB-R) and NADPH oxidase-dependent manner, leading to the phosphorylation of the AP-1 subunit c-Jun. In summation, leptin increased lung cPLA2α/COX-2 expression and leukocyte recruitment via the NADPH oxidase/ROS/AP-1 pathway...
Those results suggest that CD200–CD200R physical binding may have an important role and interactions in cell adhesion between immune cells and endothelium [19]. We confirmed here that CD200 expression in the skin microvasculature is indeed required for the specific adhesion of blood-derived monocyt...
Lymphocyte function-associated antigen (LFA-1) is a member of the beta2 family of integrins that is selectively expressed on leukocytes. Herein, we show that Ca(2)(+) mobilizing agents A23187, thapsigargin, and ionomycin induce an increase in adhesion to the LFA-1 ligand intercellular adhesion...