leading to the production of type I interferons(IFN伪/尾),inflammatory cytokines,and chemokines,or the activation of autophagy or apoptosis to inhibit virus replication.In the case of RABV,the innate immune response is usually triggered when the skin or muscle is bitten or scratched.However,RABV ...
Innate immune cells have complex signalling pathways for sensing pathogens and initiating innate immune responses against infection. These pathways are tightly regulated at different levels, including by epigenetic regulators. In this Review, we discuss
This problem is compounded with multi- and extremely drug resistant strains of TB. We hypothesize that a number of genes in the Mtb genome inhibit innate immune effector cells. To identify such gene products, we developed an innate immune response colorimetric reporter assay in macrophages and ...
Regulation of innate immune response by miRNAs up-regulated in Stevens-Johnson syndrome with severe ocular complications doi:10.1038/s41598-025-85528-8Stevens-Johnson syndromemiRNAsPlasmaInnate immunitySevere ocular complicationsStevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe ...
Careful targeting of these cells could have therapeutic benefits for several types of trauma and disease specific to the central nervous system. This Review discusses the molecular details underlying the innate immune response in the brain during infection, injury and disease. This is a preview of ...
Adrenergic regulation of the innate immune response in common carp (Cyprinus carpio L.). Dev. Comp. Immunol. 36 (2), 306-316.Chadzinska, M., Tertil, E., Kepka, M., Hermsen, T., Scheer, M., Lidy Verburg-van Kemenade, B.M., 2012. Adrenergic regulation of the innate immune ...
function by degrading intracellular pathogens; on the other hand, autophagy modulates pathogen recognition and downstream signaling for innate immune responses. ... EO Ji,HK Lee - 《Frontiers in Immunology》 被引量: 51发表: 2012年 Autophagy and the regulation of the immune response recent advances...
网络释义 1. 免疫调节 1.免疫调节(regulation of immune response)2.自然调节T细胞(innate regulatory T cells) 3.适应性调节T细胞(adaptive regulato… www.jpkc.sdu.edu.cn|基于3个网页
The instigation of the innate immune response commences as a result of the recognition of an invading pathogen by organ-specific resident macrophages, dendritic cells (DCs), fibroblasts, pericytes, and in many cases endothelial cells [1,2,3,4]. This recognition is accomplished by cytosolic or me...
Mutations of the threonine-phosphatase, but not the tyrosine-phosphatase, abolished the ability of EYA4 to enhance the innate immune response, suggesting that EYA regulates the innate immune response by modulating the phosphorylation state of signal transducers for the intracellular pathogens. This is ...