Calcium and iron nanoparticles: A positive modulator of innate immune responses in strawberry against Botrytis cinereaAntioxidant enzymesCell wall fractionsDisease severityVitaminsMineralsPhenolicFlavonoidBotrytis cinerea is considered one of the most important diseases, causing significant loss of strawberry ...
Mitogen-activated protein kinases facilitate many cellular processes and are essential for immune cell function. Their activity is controlled by kinases and dual-specificity phosphatases. A comprehensive microarray analysis of human leukocytes identifiedDUSP2(encoding the phosphatase PAC-1) as one of the ...
Bone morphogenetic protein (BMP) is a kind of classical multi-functional growth factor that plays a vital role in the formation and maintenance of bone, cartilage, muscle, blood vessels, and the regulation of adipogenesis and thermogenesis. However, understanding of the role of BMPs in antiviral ...
Virus-triggered induction of type I IFNs is delicately regulated to ensure proper but not excessive innate immune response. To further elucidate the mechanisms of virus-triggered IFN induction, we performed expression screens to unambiguously identify proteins that can activate the IFN-β promoter. The...
Inflammatory immune responseToll-like receptor stimulationcARTHLA-B*57 affects the course of HIV infection. Under antiretroviral therapy, its effects cannot be explained by outstandingly efficient T cell responses alone but may also involve cells of innate immunity. Studying in vitro stimulation with ...
Results The study revealed that 12 h of S. aureus and 80 h of P. mirabilis subsequent infections reduced the life-span of 80% of the infected nematodes. Real time PCR analyses indicated the regulation of innate immune regulatory genes, lysozyme, CUB-like proteins, neuropeptide-like factors, ...
Regulation of STAT3 in HER2-positive breast cancer. In HER2-positive breast cancer, STAT3 is activated through the EGFR/Src and IL-6/JAK pathways. This leads to abnormally high-level expression of STAT3 in HER2-positive breast cancer. Currently, HER2 inhibitors (trastuzumab, pertuzumab, and lapat...
Chronic pain poses a clinical challenge due to its associated costly disability and treatment needs. Determining how pain transitions from acute to chronic is crucial for effective management. Upregulation of the chemokine C-X-C motif ligand 12 (CXCL12)
Takaoka, A.et al.DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.Nature448, 501–505 (2007). ArticleADSCASPubMedGoogle Scholar Rebsamen, M.et al.DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.EMBO Re...
Since TBK1 is involved not only in autophagy signaling but also in the regulation of innate immune responses, we examined whether loss of FIP200 influences TLR3/TLR4-induced IFN-β production through TBK1-TAX1BP1-SQSTM1/p62 aggregate formation.Fip200KO, FIP200 WT and FIP200 ΔCT MEFs were ...