CNP-treatment of leaves produced significant improvement in the plant's innate immune response through induction of defense enzyme activity, upregulation of defense related genes including that of several antioxidant enzymes as well as elevation of the levels of total phenolics. It is also possible ...
Mitogen-activated protein kinases facilitate many cellular processes and are essential for immune cell function. Their activity is controlled by kinases and dual-specificity phosphatases. A comprehensive microarray analysis of human leukocytes identified
Virus-triggered induction of type I IFNs is delicately regulated to ensure proper but not excessive innate immune response. To further elucidate the mechanisms of virus-triggered IFN induction, we performed expression screens to unambiguously identify proteins that can activate the IFN-β promoter. The...
The immune response requires a timely interaction among different cell types within distinct microenvironments. Our studies have focused on the regulation ... F Sallusto,A Lanzavecchia - 《Immunological Reviews》 被引量: 1287发表: 2003年 Origin and development of dendritic cells Summary: Dendritic ce...
Chronic pain poses a clinical challenge due to its associated costly disability and treatment needs. Determining how pain transitions from acute to chronic is crucial for effective management. Upregulation of the chemokine C-X-C motif ligand 12 (CXCL12)
【1】 Emotion regulation improves with age. We see improvement for most people, but not for everyone. Why some people do not experience these improvements Most of the people in these studies are people from Western rich societies. 【2】 And most of them are middle-class people who are ...
The CAMP gene is regulated at the level of transcription by the bioactive form of vitamin D, 1,25(OH)2D, and the vitamin D receptor[20–22]. The hCAP18/LL-37 protein is expressed by a wide array of immune cells[23, 24] and tissues that are constantly exposed to microbes including ...
Inhibition of GSK-3β may inhibit tumor growth and improve survival through several complimentary mechanisms that include enhancement of chemotherapy activity, activation of innate anti-tumor immunity and regulation of gene expression, le...
accumulating data suggests that BMPs also play an important roles in the regulation of immune responses22,23,24,25,26,27. For example, BMP7 has been shown to drive Langerhans cell differentiation28. BMP6 has anti-HCV activity independently of IFN, but can also enhance the response to IFN29...
Takaoka, A.et al.DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.Nature448, 501–505 (2007). ArticleADSCASPubMedGoogle Scholar Rebsamen, M.et al.DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.EMBO Re...