Tuft cells are ideally positioned as chemosensory sentinels that can detect and relay informationfrom diverse luminal substances via what appear to be stereotyped outputs toinitiate both positive and aversive responses through populations of immune and neuronal cells. Despite recent insights, numerous ...
M. Regulation of immune responses by tuft cells. Nat. Rev. Immunol. 19, 584–593 (2019). Article CAS PubMed PubMed Central Google Scholar Nadjsombati, M. S. et al. Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit. Immunity 49, 33–41.e7 (...
Chemokines have fundamental roles in regulating immune and inflammatory responses, primarily through their control of leukocyte migration and localization. The biological functions of chemokines are typically mediated by signalling through G protein-coupled chemokine receptors, but chemokines are also bound by...
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes Nature, 415 (2002), pp. 922-926 View in ScopusGoogle Scholar [6] M. Pellegrini, G. Belz, P. Bouillet, A. Strasser Shutdown of an acute T cell immune response to viral infection is mediated by the...
14 Whilst functional Tregs are important for maintaining tissue homeostasis, the pathways they utilise may be hijacked by cancer cells to modulate the host immune system and dampen anti-tumour responses. As such, inhibition of Tregs and/or downstream pathways have emerged as promising candidates to ...
M. Regulation of immune responses by tuft cells. Nat. Rev. Immunol. 19, 584–593 (2019). Article CAS PubMed PubMed Central Google Scholar Nadjsombati, M. S. et al. Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit. Immunity 49, 33–41.e7 (...
Conserved microbial patterns mediate the induction of immune responses in vertebrates and Drosophila (Akira et al., 2006; Hultmark, 2003). First, microbe-derived molecules called pathogen-associated molecular patterns (PAMPs) can be detected and stimulate immune pathways such as the Toll and Imd-Rel...
Hypoxic responses are mediated by hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor that is composed of an oxygen-regulated α-subunit (HIF-1α or HIF-2α) and a constitutively expressed β-subunit (HIF-1β)11,12. HIF-1α is unstable under normoxic conditions, ...
At the intersection of genetic, environmental, dietary, and microbial factors lies the intestinal epithelial layer. The epithelium forms the interface between gut microbes and dietary factors in the gut lumen and the immune cells present in the intestinal mucosa [9]. In this review, we will focus...
The role of apoptosis in termination of immune responses has also been reported [5], [6]. Given the crucial role of apoptosis in physiology, it is not surprising that deregulation of apoptotic machinery is associated with various diseases as well as abnormalities in development. A number of ...