Aerobic and anaerobic energy production in juvenile roach (Rutilus rutilus): regulation of glycolytic process by ethofumesate at two temperaturesdoi:10.1007/s11356-016-6661-xEnvironmental Science and Pollution Research - The aim of this study was to evaluate the coupled impact of an herbicide, etho...
28 suggested that by switching the glycolytic phenotype toward OXPHOS, this could cause the cancer cells to die. In addition, the restoration of the mitochondrial-K+ channel function was enough to enhance apoptosis because the mitochondrial-K+ channel axis of cancer cells was suppressed. This ...
Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2). Autophagy. 2018;14:671–84. Article CAS PubMed Google Scholar Lee H-J, Li C-F, Ruan D, He J, Montal ED, Lorenz S, et al. Non-proteolytic ubiquitination of ...
Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic regulation of the immune system is important in the pathogenesis and progression of numerous diseases, such as cancers, autoim...
enter the cycle. A large number of compounds—for example, fatty acids and amino acids—can be metabolized to TCA cycle intermediates. High concentrations of citrate indicate a plentiful supply of intermediates for energy production; therefore, high activity of the glycolytic pathway is not required...
The inflammatory expression of GLUTs, such as GLUT-1, leads to increases in glucose concentration in cells, along with the upregulation of glycolytic flux (Gallagher et al., 2020). This increase in glucose uptake is associated with elevated levels of proinflammatory cytokines and the proliferation...
(usually < 10%) as the mechanical stimulus for the cultured SCs. Typically, engineered expression of MscL-G22S in SCs activated by low-intensity mechanical stretching induces a significant increase of Ca2+influx and upregulation of glycolytic flux, oxidative metabolism, and lipid synthesis in ...
A set of key players, AMPK and TORC1, collaborate to regulate apoptosis. When glycolytic rates are low and the AMP: ATP ratio is high, AMPK inhibits TORC1, which in turn inhibits the rate of translation and promotes apoptosis (1). Interestingly, the cellular energy state of neurons in the...
2. Glycolytic enzymes are regulated. The regulatory enzymes of glycolysis are: o hexokinase o 6-phosphofructo-1-kinase (PFK1; committed step) o pyruvatekinase These enzymes are regulated by small-molecular weight regulators (allosteric regulation) and by hormones on the genetic level (enzyme synthes...
While pyruvate kinase is a glycolytic enzyme, pyruvate carboxylase and phosphoenolpyruvate carboxykinase are involved in gluconeogenesis. Pyruvate carboxylase is subjected to control by metabolites. In particular, the requirement of this enzyme for acetyl-CoA functions as a positive allosteric effector. The...