This chapter describes the regulation of hepatic glycolysis, and gluconeogenesis at the step of phosphofructokinase/FDPase. Liver PFK is an allosteric enzyme with respect to its substrate F-6-P. The degree of co-operativity depends strongly on the pH value and on the concentration of allosteric ...
Start C, Newsholme EA. 1970. A switch mechanism in the regulation of glycolysis and gluconeogenesis in rat liver. FEBS Lett 6:171-173.Start C , Newsholme EA . 1970 . A switch mechanism in the regulation of glycolysis and gluconeogenesis in rat liver . FEBS Lett 6 : 171 – 173 ....
1、 Regulation of glycolysis 1.When ATP levels are sufficient, glycolysis activity decreasesHexokinaseinhibitedbyexcessglucose6-phosphatePFK-1isinhibitedbyATPandcitratePyruvatekinaseisinhibitedbyATP2.When ATP is needed, glycolysis is activatedAMP(theproductofATPconsumption)relievetheinhibitionofPFK-1by 2、ATP...
Although this process is not part of carbohydrate metabolism, it may be regarded as the terminal step of metabolism, wherein pyruvate—the product of glycolysis—is oxidated. The oxidative transformations of carbohydrates (pentose pathway, or pentose-phosphate cycle) also begin with a glucose monopho...
A metabolic bifurcation to glycolysis and gluconeogenesis, below and above the triosephosphates level respectively, has then been shown to be easily maintained in liver. It is suggested that the induction of glucokinase and pyruvate kinase in diabetic animals after insulin administration is a sequential...
Objectives Identify the key enzymes involved in glycogen metabolism & how they are regulated by hormones through protein kinases Describe the process of glucose uptake including the role of insulin, Integrate the metabolic pathways of glycolysis, glycogen metabolism & gluconeogenesis to explain how the ...
Glucose-stimulated insulin release from a pancreatic β-cell. Exogenous glucose is taken up by GLUT2 and undergoes glycolysis inside the cell. Elevated adenosine triphosphate (ATP) levels alter the ATP/ADP ratio, which in turn leads to the closure of ATP-sensitive K+-channels. The subsequent me...
The liver has a major role in the control of glucose homeostasis by controlling various pathways of glucose metabolism, including glycogenesis, glycogenolysis, glycolysis and gluconeogenesis. Both the acute and chronic regulation of the enzymes involved in the pathways are required for the proper ...
【生物化学】Regulation of CHO Metabolism 1Regulationofglycolysis 1.WhenATPlevelsaresufficient,glycolysisactivitydecreases ☺Hexokinaseinhibitedbyexcessglucose6-phosphate ☺PFK-1isinhibitedbyATPandcitrate☺PyruvatekinaseisinhibitedbyATP 2.WhenATPisneeded,glycolysisisactivated ☺AMP(theproductofATPconsumption)...
Short-chain fatty acids (SCFAs) are capable of increasing the mRNA expression of glucose transporter 2 (GLUT-2) and glycogen synthase 2 (GYS2) in the liver, thereby reducing hepatic glycolysis and gluconeogenesis while increasing glycogen synthesis [17, 67]. In adipose tissue, SCFAs can promote...