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The liver has a major role in the control of glucose homeostasis by controlling various pathways of glucose metabolism, including glycogenesis, glycogenolysis, glycolysis and gluconeogenesis. Both the acute and chronic regulation of the enzymes involved in the pathways are required for the proper ...
Micro-RNA-27a/b negatively regulates hepatic gluconeogenesis by targeting FOXO1. Am. J. Physiol. Endocrinol. Metab. 317, E911–E924 (2019). Article CAS PubMed Google Scholar Gerin, I. et al. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. ...
Functional roles of β-hydroxybutyrate in the regulation of renal gluconeogenesis were investigated by metabolome analysis and RNA-seq analysis of proximal tubule cells. Results Renal gluconeogenic genes were transactivated concurrently with blood β-hydroxybutyrate uprise under ketogenic states, but the ...
These concentrations are maintained by gluconeogenesis, primarily in the liver, and are regulated by glucagon, cortisol, and other counter-regulatory hormones [1]. Counter-regulatory responses of corticotropin-releasing hormone, vasopressin, and adrenocorticotropin to an insulin challenge are similar to ...
supported by the significant shared influence of the c2 carbon sources on the genes of gluconeogenesis and the tricarboxylic acid pathway. besides this and other examples that can be easily explained by current knowledge, there are also many interactions that might represent as of yet unknown ...
Rhodococci are studied for their bacterial ligninolytic capabilities and proclivity to accumulate lipids. Lignin utilization is a resource intensive process requiring a variety of redox active enzymes and cofactors for degradation as well as defense agai
metabolites and transcripts encoding for enzymes in the pathways associated with “glycolysis/gluconeogenesis”, “tricarboxylic acid (TCA) cycle”, “branched chain amino acid (BCAA) degradation”, and “pentose phosphate pathway”, among others, were significantly enriched in the muscle of DTG mice ...
CREBH maintains circadian glucose homeostasis by regulating hepatic glycogenolysis and gluconeogenesis. Mol. Cell Biol. 37, e00048-17 (2017). PubMed PubMed Central Google Scholar Lee, M. W. et al. Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. Cell Metab. ...
We also found that this regulation of gluconeogenesis was not dependent on differences in activity between Akt1 or Akt2. While we cannot rule out the possibility that the various Akt isoforms may interact with different downstream mediators or have different subcellular localization, our data suggest ...