P., McCulloch, C. A. Regulation of IL-1 signaling through control of focal adhesion assembly.doi:10.1096/fj.201700966RQin WangMatrix Dynamics Group Faculty of Dentistry University of Toronto Toronto Ontario CanadaJulie DelcordeMatrix Dynamics Group Faculty of Dentistry University of Toronto Toronto ...
Cell adhesion encompasses both cell-cell and cell-ECM interactions, which are regulated by the assembly of dynamic multi-protein complexes called focal adhesions (FAs). Focal adhesions play a critical role in organizing tissue structure, mediating cell interactions, and regulating signal transduction ...
Liu BP, Chrzanowska-Wodnicka M, Burridge K. 1999. Regulation of cell contractility by RhoA: Stress Fiber and focal adhesion assembly. In: Guan J-L, editor. Signaling through Cell Adhesion Molecules. New York: CRC Press. p 245-259.
Serrels, B. et al. Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.Nat. Cell Biol.9, 1046–1056 (2007). ArticleCASGoogle Scholar Geiger, B. A 130 K protein from chicken gizzard: its localization at the termini of microfilament bundles...
Herein, we show that the assembly and turnover of focal adhesions, the phosphorylation of FAK and paxillin, and the reorganisation of F-actin in MSCs are closely related to their differentiation states in response to SDF-1α. Upon SDF-1α stimulation, FAs turnover more rapidly with the most...
The role of force in focal adhesion assembly has been studied using several techniques. Balaban et al. [166] simultaneously measured cell displacements and focal adhesions (visualized by vinculin:GFP) to demonstrate that increased force is correlated with increased focal adhesion formation. Other ...
Most of these proteins are modular, integrating actin binding, protein-protein interaction, membrane-binding, and signaling domains. In response to extracellular signals, often mediated by Rho family GTPases, ABPs control different steps of actin cytoskeleton assembly, including filament nucleation, ...
Buhl AM, Johnson NL, Dhanasekaran N, Johnson GL (1995) G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J Biol Chem 270:24631–24634 Article CAS PubMed Google Scholar Goulimari P, Kitzing TM, Knieling H et al (2005) Galpha12/13...
Furthermore, NHE1 possesses actin-anchoring functions which are also regulating the cytoskeletal organization, the assembly of focal adhesions, the formation of actin stress fibers, and cell shape independently of its ion translocation function (Tominaga and Barber, 1998; Vexler et al., 1996). In ...
In response to vascular injury vascular smooth muscle cells (VSMCs) alternate between a differentiated (contractile) and a dedifferentiated (synthetic) state or phenotype. Although parts of the signaling cascade regulating the phenotypic switch have been