Serrels, B. et al. Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.Nat. Cell Biol.9, 1046–1056 (2007). ArticleCASGoogle Scholar Geiger, B. A 130 K protein from chicken gizzard: its localization at the termini of microfilament bundles...
A crucial early event by which cancer cells switch from localised to invasive phenotype is initiated by the acquisition of autonomous motile properties; a process driven by dynamic assembly and disassembly of multiple focal adhesion (FA) proteins, which mediate cell–matrix attachments, extracellular ...
Gilmore AP, Burridge K (1996) Molecular mechanisms for focal adhesion assembly through regulation of protein-protein interactions. Structure 4(6):647-651Gilmore AP, Burridge K (1996) Molecular mechanisms for focal adhe- sion assembly through regulation of protein-protein interactions. Structure 4(...
Despite being both sufficient and necessary for the assembly or maintenance of stress fibers, DAP kinase is incapable of stimulating the formation of focal adhesions in quiescent cells. Moreover, it promotes the disassembly of focal adhesions but not stress fibers in cells receiving serum factors. ...
Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassemblyNat. Cell Biol.10.1038/ncb3257 Horton, E.R., Byron, A., Askari, J.A., Ng, D.H.J., Millon-Frémillon, A., Robertson, J.et al. (2015) . 17, 1577–1587 Google Scholar 10. ...
In the first part of my work, I shown that ICAP-1alpha specifically slow-downs adhesion assembly by maintaining the low affinity state of beta1 integrin. Surprisingly, I found an unexpected function of ICAP-1alpha in the sensing of low extracellular matrix densities and in the adaptation of ...
Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability. A novel mechanism regulating smooth muscle cell ... Smooth muscle cell (SMC) proliferation is suppressed in intact blood vessels but stimulated in atherosclerosis, restenosis after angioplasty,...
For example, recent studies have shown that oxidative stress induced Cav-1 phosphorylation at tyrosine 14 (56, 57), which has been proposed to play a role in cancer cell migration through the regulation of focal adhesion (21). The expression of Cav-1 is tightly regulated at various levels,...
Herein, we show that the assembly and turnover of focal adhesions, the phosphorylation of FAK and paxillin, and the reorganisation of F-actin in MSCs are closely related to their differentiation states in response to SDF-1α. Upon SDF-1α stimulation, FAs turnover more rapidly with the most...
The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibres in response to growth factors. Cell 70, 389–399 (1992). 20. Riento, K. & Ridley, A. J. Rocks: multifunctional kinases in cell behaviour. Nat. Rev. Mol. Cell Biol. 4, 446–456 (...