The regulation of fatty acid synthase (FAS) expression by sterols in a cultured human hepatoblastoma cell line, Hep G2, was studied. When cells were treated with compactin in a medium containing lipoprotein deficient serum, FAS mRNA level increased 1.6-fold. A squalene synthase inhibitor, TAN...
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her... NIH-3T3/Her-2 cells demonstrated a significant upregulation of FAS protein expression, which was dependent on the upstream activation of mitogen...
Fatty acid synthase (FAS)1 plays a central role in de novo lipogenesis in mammals and birds. By action of its seven active sites, FAS catalyzes all the reaction steps in the conversion of acetyl-CoA and malonyl-CoA to palmitate. FAS activity is not known to be regulated by allosteric effe...
Accordingly, inhibition of fatty acid synthase—a key enzyme that mediates lipogenesis—blunted the effects of Agrp neuron activation on substrate utilization. In pair-fed conditions during positive energy balance, activation of Agrp neurons improved metabolic efficiency, and increased weight gain and ...
Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma. Anticancer Res. 24, 4169–4173 (2004). CAS PubMed Google Scholar Mashima, T., Seimiya, H. & Tsuruo, T. De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy....
Fatty acid synthase (FASN) is a central enzyme of lipid metabolism that can catalyse de novo fatty acid (FA) biosynthesis to promote cell growth and survival [9]. For instance, loss of FBXW7β function facilitates FASN protein stability and promotes lipogenesis and growth in CRC [10]. ...
J Li,K Defea,RA Roth - 《Journal of Biological Chemistry》 被引量: 952发表: 1999年 Insulin Stimulation of the Fatty Acid Synthase Promoter Is Mediated by the Phosphatidylinositol 3-Kinase Pathway INVOLVEMENT OF PROTEIN KINASE B/Akt Fatty acid synthase (FAS) is a critical enzyme in de novo ...
The hepatic lipogenic enzyme, fatty acid synthase (FAS) is n... E Duplus,C Forest - 《Biochemical Pharmacology》 被引量: 51发表: 2002年 A Molecular Mechanism of Polyunsaturated Fatty Acid Regulation of Gene Transcription This article reviews polyunsaturated fatty acid, particularly those of n 3...
1 (ACC1), which catalyzes the rate-limiting step in FA synthesis by converting acetyl-coA to malonyl-coA, and (2) sterol regulatory element-binding protein 1c (SREBP1c), a transcription factor that promotes the expression of multiple lipogenic enzymes, including ACC1 and FA synthase.49...
A. et al. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc. Natl Acad. Sci. USA 101, 10715–10720 (2004). CAS PubMed Google Scholar Wang, X., Sun, Y., Wong, J. & Conklin, D. S. PPARγ maintains ERBB2-positive...