activity-independent manner [45]. Interestingly, loss ofRanBP2andHDAC7significantly reduces the size and number of PML NBs, while knockdown ofPIAS1increases PML NBs [42,43,44,45]. Several pathways or factors have been found to promote PML desumoylation including the SUMO-specific protease (SEN...
E. et al. ATP–citrate lyase links cellular metabolism to histone acetylation. Science 324, 1076–1080 (2009). Article CAS PubMed PubMed Central Google Scholar Bhanu, N. A.-S., L. & Garcia, B. A. Quantification of lysine crotonylation during in vitro human myogenic differentiation. The...
Recently, the cellular quality-control process of mitophagy has attracted considerable research interest; however, the limited availability of suitable chemical probes has restricted our understanding of the molecular mechanisms involved. Current approaches to initiate mitophagy include acute dissipation of the...
This model reproduces a variety of experimental data while providing a framework for understanding the function of the enzyme's subunits. Specifically, it explains how ATP hydrolysis can uncouple from proton movement, which has important consequences for cellular energetics and pH regulation.;Until now...
Regulation processes moderate everything from the growth and replication rates of cells to the salt levels and acidity of the cellular environment. If cell growth and replication are not moderated, cells may replicate at an uncontrollably high rate; this condition is called cancer. A great deal ...
This discovery led to the recognition of ROS as essential players in many cellular processes, including cell cycle progression. ROS influence cell cycle progression in a context-dependent manner via phosphorylation and ubiquitination of CDKs and cell cycle regulatory molecules. We show that ROS often...
The cellular redox environment required for the cell-to-cell communication that is essential for SAM maintenance can be controlled by regulation of plasmodesmatal, for example by regulation of callose deposition via a plastidial thioredoxin (TRX)m3 [14]. In addition to ROS signalling and regulation...
It has become evident that cullins are not the only class of proteins modified by NEDD8 (Table 1), indicating that neddyl?ation might regulate many cellular processes. Interestingly, several neddyl?ated proteins seem to be either substrates or components of ubiquitin E3s, revealing an intriguing...
The last decade has revealed new roles for Cullin-RING ubiquitin ligases (CRLs) in a myriad of cellular processes, including cell cycle progression. In addition to CRL1, also named SCF (SKP1-Cullin 1-F box protein), which has been known for decades as an
(Fig.1). This process is used during signaling events and in transcriptional regulation, but also plays a critical role in protein homeostasis [1]. K63-linked, linear chains or branched/mixed chains can form the scaffolding platform for further protein recruitment and signaling [7]. Cellular ...