activity-independent manner [45]. Interestingly, loss ofRanBP2andHDAC7significantly reduces the size and number of PML NBs, while knockdown ofPIAS1increases PML NBs [42,43,44,45]. Several pathways or factors have been found to promote PML desumoylation including the SUMO-specific protease (SEN...
The last decade has revealed new roles for Cullin-RING ubiquitin ligases (CRLs) in a myriad of cellular processes, including cell cycle progression. In addition to CRL1, also named SCF (SKP1-Cullin 1-F box protein), which has been known for decades as an important factor in the regulatio...
Recently, the cellular quality-control process of mitophagy has attracted considerable research interest; however, the limited availability of suitable chemical probes has restricted our understanding of the molecular mechanisms involved. Current approaches to initiate mitophagy include acute dissipation of the...
Importantly, Klotho-dependent cellular transport regulation implies stimulatory or inhibitory effects. Klotho has been shown to play a key role in the regulation of multiple calcium and potassium ion channels, and various cellular carriers including the Na+-coupled cotransporters such as NaPi-IIa, ...
This discovery led to the recognition of ROS as essential players in many cellular processes, including cell cycle progression. ROS influence cell cycle progression in a context-dependent manner via phosphorylation and ubiquitination of CDKs and cell cycle regulatory molecules. We show that ROS often...
A matter of life and (cell) death...Maintaining cellular energy balance is a key challenge for multicellular organisms. Nutrient availability and requirements are always in flux. At times, cells need to die for the health of the organism. The programming responsible for this sacrificial cell ...
On the other hand, BR regulates multiple cellular and physiological processes, with cell elongation being the major one. Many BR signaling components have been identified, and the signal transduction pathway from receptor kinase to the BZR transcription factors has been characterized in detail. In ...
Three-dimensional mesostructures as high-temperature growth templates, electronic cellular scaffolds, and self-propelled microrobots A significant disadvantage of these systems is that the elastomeric substrates, while essential to the assembly process, can impose significant engineering ... Z Yan,M Han,Y...
(Fig.1). This process is used during signaling events and in transcriptional regulation, but also plays a critical role in protein homeostasis [1]. K63-linked, linear chains or branched/mixed chains can form the scaffolding platform for further protein recruitment and signaling [7]. Cellular ...
Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular processes. Yet, excessive levels of oxidants are associated with agei