activity-independent manner [45]. Interestingly, loss ofRanBP2andHDAC7significantly reduces the size and number of PML NBs, while knockdown ofPIAS1increases PML NBs [42,43,44,45]. Several pathways or factors have been found to promote PML desumoylation including the SUMO-specific protease (SEN...
E. et al. ATP–citrate lyase links cellular metabolism to histone acetylation. Science 324, 1076–1080 (2009). Article CAS PubMed PubMed Central Google Scholar Bhanu, N. A.-S., L. & Garcia, B. A. Quantification of lysine crotonylation during in vitro human myogenic differentiation. The...
adaptors, and substrate receptors can generate hundreds of different CRL complexes that may, in turn, target thousands of substrates. Many distinct CRLs play critical roles in countless cellular processes ranging from DNA repair to cell proliferation, chromatin remodeling, DNA...
Regulation processes moderate everything from the growth and replication rates of cells to the salt levels and acidity of the cellular environment. If cell growth and replication are not moderated, cells may replicate at an uncontrollably high rate; this condition is called cancer. A great deal ...
This discovery led to the recognition of ROS as essential players in many cellular processes, including cell cycle progression. ROS influence cell cycle progression in a context-dependent manner via phosphorylation and ubiquitination of CDKs and cell cycle regulatory molecules. We show that ROS often...
Metabolic regulation is a term used to describe the process by which metabolic pathways (both the anabolic/biosynthetic and catabolic/degradative pathways) are regulated in mammals. Living organisms need to generate energy continuously to maintain cellular processes and functions. The ability to oxidize ...
Three-dimensional mesostructures as high-temperature growth templates, electronic cellular scaffolds, and self-propelled microrobots A significant disadvantage of these systems is that the elastomeric substrates, while essential to the assembly process, can impose significant engineering ... Z Yan,M Han,Y...
9、nts of each kind of cells on the basis of mastering all kinds of cellular morphology.* heres a common identification of similar cells.I. identification of primary and primary erythrocytesPrimitive granulocytePrimitive red blood cellSoma1018 microns1520 microns, showing a tumor like processCytoplasm...
(Fig.1). This process is used during signaling events and in transcriptional regulation, but also plays a critical role in protein homeostasis [1]. K63-linked, linear chains or branched/mixed chains can form the scaffolding platform for further protein recruitment and signaling [7]. Cellular ...
Recently, the cellular quality-control process of mitophagy has attracted considerable research interest; however, the limited availability of suitable chemical probes has restricted our understanding of the molecular mechanisms involved. Current approaches to initiate mitophagy include acute dissipation of the...