Positive and negative regulation of cellular immune responses in physiologic conditions and diseases. Clin. Dev. Immunol. 2012: 485781.Vigano S, Perreau M, Pantaleo G. Harari A. Positive and negative regulation
Mechanoregulation of lymphocyte cytotoxicity Cytotoxic T lymphocytes and natural killer cells destroy target cells using a mechanically active cytolytic immune synapse. This Review examines the various ways in which mechanical forces contribute to the potency, specificity and overall efficacy of the cytotoxic...
Regulation of these processes is important for proper DNA damage response and signal amplification. In this current study, we highlight a new regulatory mechanism controlling histone H2AX function. It is believed that the Y142 residue of H2AX is phosphorylated under basal conditions by WSTF5. In ...
Using mesoderm derived from human embryonic stem cells, we identified the same principle of Wnt signaling dependent EC specification in conjunction with auto-upregulation of LEF1. Our data indicate a novel role of β-catenin dependent Wnt signaling in regulating EC specification during vasculogenesis....
In this process, PhcA regulates hrpB expression in opposite ways. R. solanacearummay switch from using HrpG to PrhG for hrpB activation in a cell density-dependent manner (Zhang et al., 2013). In a previous study using transposon mutagenesis, we isolated some prh (positive regulation of ...
Using quantitative proteomics, we show that deletion of OLA1 results in the upregulation of a specific set of proteins involved in stress-protective processes, linking Ola1p to the maintenance of cellular proteostasis during heat shock. We found Ola1p in the detergent-resistant pellet fraction of...
This model, however, is of very limited help in the biotechnological regulation of differentiation. Hence, we took into account others such as the instructive, stochastic, and continuum models – considering the possibility that they can help to increase the percentage yield of a given required ...
A critical review of the literature was performed to elucidate the molecular mechanisms and mediators induced by PA that potentially impact on viral infections such as SARS-CoV2. Results We showed the effects mediated by regular moderate PA on viral adverse effects through the regulation of biologica...
h up-regulated SCPs include purine nucleotide metabolism, protein folding, metal ion homeostasis, response to stress; the 24 h:12 h down-regulated SCPs were classified into processes of carboxylic acid catabolism, cellular amino acid catabolism, peptidoglycan biosynthetic process, RNA process...
Total cellular RNA was extracted from the frozen bone tissue around the implants using the Ultrapure RNA Kit (CoWin Bioscience, Beijing, China) following the manufacturer’s instructions. The concentration of RNAs was analyzed by Nanodrop ND-2000 (Thermo, Wilmington, DE, USA) at a wavelength of...