(2011) PUMILIO-2 I is involved in the positive regulation of cellular proliferation in human adipose-derived stem cells. Stem Cells and Development, In Press. doi:10.1089/scd.2011.0143Shigunov, P., Sotelo-Silveira, J., Kuligovski, C., De Aguiar, A. M., Rebelatto, C. K., Moutinho,...
- 《Molecular & Cellular Biology》 被引量: 107发表: 2008年 Regulation of premeiotic S phase and recombination-related double-strand DNA breaks during meiosis in fission yeast. The meiotic cell cycle is characterized by high levels of recombination induced by DNA double-strand breaks (DSBs), ...
Importantly, we demonstrate in vivo relevance for both kinases in the regulation of basal mitophagy. Knockdown of GAK homologue (gakh-1) in C. elegans or knockout of PRKCD homologues in zebrafish led to significant inhibition of basal mitophagy, highlighting the evolutionary relevance of these ...
In regard to melanocytes, which can directly affect repigmentation after grafting, GSVA (Gene set variation analysis) using Reactome and GO database showed that pathways including “melanin biosynthesis”, “PI3K-AKT signaling”, “cell-cell adhesion”, and “positive regulation of melanocyte different...
Using mesoderm derived from human embryonic stem cells, we identified the same principle of Wnt signaling dependent EC specification in conjunction with auto-upregulation of LEF1. Our data indicate a novel role of β-catenin dependent Wnt signaling in regulating EC specification during vasculogenesis....
Inflammatory mediators triggered throughout healing process alter cellular responses, perhaps act at signals controlling differentiation. Objectives: The purpose of this study was to define the influence of TNF-α on stem cell signaling at osteoinductive gene promoters. Methods: Mouse pluripotent cells (...
The anti-inflammatory response induced by regular PA is mediated by skeletal muscle contraction through the release of muscle-derived cytokines (myokines). Moderate PA induces a marked increase in serum levels of cytokines involved in the regulation of inflammation, such as IL-10, IL-1 receptor ...
Total cellular RNA was extracted from the frozen bone tissue around the implants using the Ultrapure RNA Kit (CoWin Bioscience, Beijing, China) following the manufacturer’s instructions. The concentration of RNAs was analyzed by Nanodrop ND-2000 (Thermo, Wilmington, DE, USA) at a wavelength of...
The enteric neurotransmitter acetylcholine governs important intestinal epithelial secretory and immune functions through its actions on epithelial muscarinic Gq-coupled receptors such as M3R. Its role in the regulation of intestinal stem cell function a
These novel connections are highly enriched for chromatin-modifying proteins, hinting at a universal role of chromatin regulation in cancer etiology. Although infrequently mutated as single genes, we show that chromatin modifiers are altered in a large fraction of cancer patients. In summary, we ...