Acetyl-CoA carboxylase (ACC) catalyses the formation of malonyl-CoA, an essential substrate for fatty acid synthesis in lipogenic tissues and a key regulatory molecule in muscle, brain and other tissues. ACC contributes importantly to the overall control of energy metabolism and has provided an ...
These molecular insights enhance our understanding of acetyl-CoA carboxylase regulation and provide a basis for drug discovery. 展开 关键词: fatty acid metabolism metabolic syndrome enzyme regulation enzyme phosphorylation DOI: 10.1038/celldisc.2016.44 被引量: 5 ...
Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis1,2. Eukaryotic acetyl-CoA carboxylases are large, homodimeric multienzymes. Human acetyl-CoA carboxylase occurs in two isoforms: the metabolic, cytosolic ACC1, and ACC2,...
Feedback regulation of plastidic acetyl-CoA carboxylase by 18:1-acyl carrier protein in Brassica napus — Feedback inhibition of plant fatty acid synthesis... 被引量: 0发表: 0年 Acetyl-CoA Carboxylase β Gene Is Regulated by Sterol Regulatory Element-binding Protein-1 in Liver Acetyl-CoA ...
Thus, a central challenge for plant lipid research is to provide a molecular understanding of how plants regulate the major differences in lipid metabolism found, for example, in mesophyll, epidermal, or developing seed cells. Acetyl-CoA carboxylase (ACCase) is one control point that regulates ...
Acetyl-CoA carboxylase catalyses the synthesis of malonyl-CoA, the first intermediate in fatty acid (hence phospholipid) synthesis. The accBC operon from Bacillus subtilis codes for two subunits of acetyl-CoA carboxylase, biotin carboxyl-carrier and biotin carboxylase. In this work, the 5′-end ...
metabolism of fatty acids and cholesterol.80In effector CD8+T cells, SREBPs induce the expression of the rate limiting enzymes in FAS and cholesterol synthesis, such as acetyl-CoA carboxylase (ACC).74,91Additionally, PPARγ serves as a critical downstream molecule of mTORC1 in regulating fatty ...
Regulation of hepatic acetyl coenzyme a carboxylase by phosphorylation and dephosphorylation Acetyl CoA carboxylase, in a partially purified preparation, was inactivated by ATP in a time- and temperature-dependent reaction. Adenosine 3′,5′-monoph... CKH Kim - 《Archives of Biochemistry & Biophysics...
of Genes and Genomes (KEGG) analysis (Fig.3A). GO enrichment showed that secondary alcohol, cholesterol, steroid, and sterol biosynthesis were the main biological processes that were altered (Fig.3B). Interestingly, the mRNA levels of the key lipogenic enzymes acetyl-CoA carboxylase (ACC), ...
Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. J Biol Chem. 2007; 282: 26122–26131. 37 Shah US, Dhir R, Gollin SM, Chandran UR, Lewis D, Acquafondata M et al. ...