Inhibition of acetylCoA carboxylase by PP7a exerts beneficial effects on metabolic dysregulation in a mouse model of dietinduced obesityPP-7aacetyl-coenzyme A carboxylasehigh-fat diet-induced obesityobesitylipid metabolismAcetyl-coenzyme A carboxylase (ACC) is a critical regulator of fatty acid ...
ACC catalyzes the initial and rate-limiting step in fatty acid de novo synthesis synthesizing malonyl-CoA via the carboxylation of acetyl-CoA. Malonyl-CoA is used as a substrate for de novo fatty acid biosynthesis by fatty acid synthase (FAS). Fatty acids produced by FAS may be further elonga...
We demonstrate that mice with targeted loss-of-function point mutations within the AMP-activated protein kinase (AMPK) phosphorylation sites on acetyl-CoA carboxylase 1 (ACC1 Ser79Ala) and ACC2 (ACC2 Ser212Ala) have increased liver de novo lipogenesis (DNL) and liver lesions. The same ...
Escherichia coli acetyl coenzyme A carboxylase (ACC), the first enzyme of the fatty acid biosynthetic pathway, is inhibited by acylated derivatives of acyl carrier protein (ACP). ACP lacking an acyl moiety does not inhibit ACC. Acylated derivatives of ACP having chain lengths of 6 to 20 carbon...
The activity of acetyl-CoA carboxylase (ACC), a rate-limiting enzyme of fatty acid biosynthesis and malonyl-CoA production, can be regulated by several mechanisms, including multisite covalent phosphorylation, both in vitro and in intact cells. Evidence has been presented by others to indicate that...
Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects:A randomized,doubleblind,crossover study. Stiede K,Miao W,Blanchette HS,Beysen C,Harriman G,Harwood Hj jr,Kelley H,Kapeller R,Schmalbach T,Westlin WF. Hepatology . 2017...
Explores inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein. First enzyme of the fatty acid biosynthetic pathway; Acylated derivatives of acyl carrier protein; Regulation of membrane lipid synthesis; Inability of the palmitoyl thioester of spinach acyl carrier protein...
In higher plants the biosynthetic machinery of de novo fatty acid biosynthesis, measured as [ 14 C]acetate incorporation into fatty acids, is predominantly located in plastids. A key enzyme in this pathway is the biotin-containing acetyl-CoA carboxylase
Activation of AMPK was also demonstrated by measuring the phosphorylation of acetyl-CoA carboxylase, a substrate of AMPK, correlated with a subsequent increase in fatty acid oxidation. All of these effects were abolished by the mitogen-activated protein kinase kinase inhibitor PD98059. Treatment of ...
Results support the interpretation that the observed inhibition of pyruvate carboxylase occurred primarily by depletion of the activator, acetyl CoA, through sequestration of coenzyme A during benzoate metabolism. 展开 关键词: Animals Rats, Inbred Strains Rats Mitochondria, Liver Hippurates Carbon Dioxide ...