The genital ridge is composed of somatic cell lineages and germ cells. However, these two lineages are formed at different developmental stages and positions in the embryo. Progenitor cell formation of germ cells begins with activation of PR domain zinc finger protein (Prdm) 1 (also known asBlim...
Int Rev Neurobiol 60, 153–181. Article PubMed CAS Google Scholar Miska, E. A., Alvarez-Saavedra, E., Townsend, M., Yoshii, A., Sestan, N., Rakic, P., Constantine-Paton, M. & Horvitz, H. R. (2004). Microarray analysis of microRNA expression in the developing mammalian brain....
153, 154, 155, 156 Here, we highlight some of the bacterial components and their receptors that participate in regulating gut barrier integrity. IECs express TLR2 that recognizes bacterial lipopeptides, lipoteichoic acid and yeast zymosan, and forms heterodimers with TLR1 or TLR 6.157 Ligand-...
TNF receptor-associated factor (TRAF3), TANK-binding kinase 1 (TBK1), NF-kappa-B essential modulator (NEMO), and IĸB kinase-ε (IKKε) through posttranslational modifications (PTMs) or other regulatory mechanisms and viral proteins interacting with MAVS, TRAF...
cGAS pathway by self DNA can also lead to autoimmune and inflammatory disease. Thus, the cGAS pathway must be properly regulated. Here we review the recent advances in understanding of the cGAS–STING pathway, focusing on the regulatory mechanisms and roles of this pathway in heath and disease....
154-169 View in ScopusGoogle Scholar [56] J. Heredia, L. Mukundan, F. Chen, A. Mueller, R. Deo, R. Locksley, T. Rando, A. Chawla Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration Cell, 153 (2) (2013), pp. 376-388 View in ScopusGoogle...
The miR-34a for example is downregulated in metastatic HCC tissues, and has been reported to inhibit HCC glycolysis by directly targeting HK1, HK2, and glucose-6-phosphate isomerase (GPI) [153]. The miR-199a-5p is also down-regulated in HCC tissues, and is associated with the tumor size...
[151,152], and influencing nucleosome positioning [153]. Polymorphic short tandem repeats are estimated to account for 10-15% of the variance in gene expression [146]. In particular, 10-20% of eukaryotic genes and promoters contain an unstable repeat tract [154], and changes in repeat ...
PPARα and PPARγ indirectly impact the pro-inflammatory transcription factor. In particular, the promoter of the gene-coding IκBα is controlled by PPAR [153]. Owing to this, PPARα [154,155] and PPARγ [156] increase expression of IκBα—protein binding NF-κB. As a result, inactive...
Family processes such as maternal parenting and family screen exposure are significantly related to children’s gains in behavioral self-regulation, but the potential mechanism of these relations remains unknown. In this study, we investigated how matern