Plasma LH was measured using a Rodent LH ELISA kit (Endocrine Technologies, Newark, CA) with a sensitivity of 0.03 ng ml−1 and 7% intra-assay and 10% inter-assay coefficients of variance. Image analysis For confocal observations and analyses, an inverted laser scanning Axio observer ...
Sustained production of ROS in MCF-7 mainly activates survival signalling, facilitates oestrogen unresponsiveness, increases aggressive growth potential, and enables resistance to endocrine therapy [39]. Thus, we proposed that increased antioxidant enzymes and reduced ROS levels balanced the oxidative status...
Our work demonstrates a key role of inter-organ communication between the midgut, the brain and endocrine organs to regulate energy homoeostasis. Results Midgut NPF is required for lipid accumulation in the fat body and promotes starvation resistance...
These findings demonstrate an endocrine role of salivary glands in the control of systemic growth and provide novel insights into inter-organ communication between the salivary gland and other body parts. Results Ablation of the salivary glands retards systemic growth To determine novel functions of ...
Endocrine PathologyMiyakoshi T, Takei M, Kajiya H, Egashira N, Takekoshi S, Teramoto A, Osamura RY (2008) Expression of Wnt4 in human pituitary adenomas regulates activation of the beta-catenin-independent pathway. Endocr Pathol 19(4):261–273...
We continued to broaden the participation of PTPRA phosphatase in controlling RET by studying its tumorigenic missense mutants, MEN2A and MEN2B, responsible for multiple endocrine neoplasms (MEN) of the thyroid and adrenal glands (Figure 6A). Reportedly, the MEN2A mutation (C634W) triggers RET ...
What are the major endocrine glands? Which tissues also produce hormones? In which cells are the male sex hormones produced? What are those hormones? How is their production regulated? Which of the following is NOT a function of the...
and intracrine FGF receptor pathways. These FGF-23 regulatory pathways may enable systemic phosphate and vitamin D homeostasis to be coordinated with bone mineralization. FGF-23 also functions as a counter-regulatory hormone for 1,25-dihydroxyvitamin D in a bone–kidney endocrine loop. FGF-23, ...
pathophysiology of aging-associated dry eye syndrome. Further investigation of the clinical relevance of 5-HT in dry eye syndrome and other hormonal effects on LG secretory function will advance our understanding of both the pathogenesis of dry eye syndrome and therapeutic interventions for this ...
(Fig.3f). Histological examination by hematoxylin and eosin staining revealed severe malignant progression in TRAMP;Usp11-/Ymice, whereas the prostate glands of age-matched TRAMP;Usp11+/Ymice were preserved and the tissue showed a PIN phenotype (Fig.3g). It is worth noting that TRAMP;Usp11-...