6). Further study with Regnase-1 gene knockout mice in our next work will strengthen the persuasion of this conclusion. In our study, both mRNA and protein levels of Regnase-1 were very low in quiescent microglia. Stimulation by HMGB1 significantly promoted Regnase-1 expression both in vitro ...
GENETICALLY ENGINEERED T CELLS WITH REGNASE-1 AND/OR TGFBRII DISRUPTION HAVE IMPROVED FUNCTIONALITY AND PERSISTENCEA population of genetically engineered T cells, comprising a disrupted Reg1 gene and/or a disrupted TGFBRII gene. Such genetically engineered T cells may comprise further genetic ...
控制HSC谱系启动的Reg1/Reg3-Nfkbiz轴模型 生长发育;淋巴,髓系,造血干细胞,谱系,分化,scRNA-seq,scATAC-seq;Takuya Uehata, Shinnosuke Yamada, Osamu Takeuchi; Kyoto University; Japan. 2、空间转录组学揭示睡眠不足导致的不同脑区独特的基因表达变化 Spatial transcriptomics reveals unique gene expression changes...
Regnase-1 acts like a pair of scissors, chopping up inflammation-associatedgene productsso they can't be expressed. By targeting genes turned on in response to inflammation, Regnase-1 prevents the body's immune system from going haywire. However, through a process called phosphorylation, Regnase-...
RNA-binding proteins regulate RNA fate and govern post-transcriptional gene regulation. A new family of RNA-binding proteins is represented by regulatory RNases (Regnase, also known as Zc3h12 or MCPIP), which have emerged as important players in immune homoeostasis. Four members, Regnase1-4, ...
Toaddresscell-intrinsice,,ectsmediatedbyREGNASE-1(weper)ormed RNAsequencing(RNA-seq)o,REGNASE-1-nullandwild-typeOT-Icells isolated,romtheinvivodualtrans,ersystem.Genesetenrichmentanal-ysis(GSEA)usinggenemodulesassociatedwith di,(erent)unctional stateso,tumour-in,iltratingCD8+Tcells11revealedthattumour...
Here, we provide a comprehensive update on the function, regulation and molecular mechanisms of Regnase-1, and we propose that Regnase-1 may function as a master rapid response gene for cellular adaption triggered by microenvironmental changes....
states including autoimmune diseases,cancer and cardiovascular diseases.Here,we provide a comprehensive update on the function,regulation and molecular mechanisms of Regnase-1,and we propose that Regnase-1 may function as a master rapid response gene for cellular adaption triggered by microenvironmental ...
GENETICALLY ENGINEERED T CELLS WITH REGNASE-1 AND/OR TGFBRII DISRUPTION HAVE IMPROVED FUNCTIONALITY AND PERSISTENCEA population of genetically engineered T cells, comprising a disrupted Reg1 gene and/or a disrupted TGFBRII gene. Such genetically engineered T cells may comprise further genetic ...
The results of cell experiments showed that si-Regnase-1 significantly reduced the mRNA and protein levels of TRAF6 in Jurkat T cells and increased the expression level of inflammatory gene TNF-伪. Co-immunoprecipitation assay further verified the binding between the two proteins. Regnase-1 may ...