Here, we report the catalytic activity of two S-selective imine reductases towards 3,4-dihydroisoquinolines and 3,4-dihydro-尾-carbolines and their activity in the direct reductive amination of ketone substrates. The crystal structures of the enzyme from Streptomyces sp. GF3546 in complex with ...
More importantly, Wetzl and coworkers recently reported the preparative scale application (100 mg) of an imine reductase in ketone amination. The results suggested that reductive amination using IREDs was feasible for the synthesis of chiral amines, thereby overcoming the problem of thermodynamic ...
, the reductive amination of the unsaturated ketone 1-acetylcyclohexene withbenzylamine, which was very slow with NaBH(OAc)3, proceeded very fast under Mattson’s modified conditions to give a quantitative yield of the reductive amination product (Table 7, entry 6). The reductive amination of...
Direct reductive amination of ketones by reductive aminases (RedAms) is a promising method for the synthesis of primary, secondary and tertiary amines. In this work, five naturally occurring RedAms possessing reductive ami
The asymmetric reductive amination of ketones enables the one-step synthesis of chiral amines from readily available starting materials. Here we report the discovery of a family of native NAD(P)H-dependent amine dehydrogenases (nat-AmDHs) competent for t
NaBH4can be a perfectly acceptable reducing agent for reductive amination. There’s one slight problem with this reagent, however. What if the NaBH4ends up reducing the aldehyde or ketone before it has a chance to react with the imine? That would lead to lower yields.[In practice, this can...
Amine synthesis by reductive amination (reductive alkylation)
The processes include admixing a ketone with an amine in the presence of a catalyst having a chiral phosphine ligand and an acid. ... X Zhang - US 被引量: 133发表: 2004年 The First Highly Enantioselective Homogeneously Catalyzed Asymmetric Reductive Amination: Synthesis of α-N-Benzylamino ...
A family of native amine dehydrogenases for the asymmetric reductive amination of ketones. Nat. Catal. 2, 324–333 (2019). Article CAS Google Scholar Yang, Y., Cho, I., Qi, X., Liu, P. & Arnold, F. H. An enzymatic platform for the asymmetric amination of primary, secondary and ...
2-additiontoiminesandasymmetricamination ofa,a-disubstitutedaldehydes, [2] transformationofallylic alcoholsintoamines, [3] (dynamic)kineticresolution, [4] and cyclicderacemization [5] employingracemicaminesassub- strates.Asymmetricreductiveaminationofketoneshasbeen investigatedwithtransition-metalcatalysts [6] ...