reaction mechanismAlcohols and amines are important in pharmaceutical, perfume, and agrochemical industries. Catalytic asymmetric synthesis is one of the major ways to produce chiral alcohols/amines from prochiral ketones/imines via hydrogenation. Meanwhile, the alcohol/amine dehydrogenation with high ...
To gain insight into the mechanism of the reaction, we performed deuterium-labeling experiments. First, the reaction of1agwas carried out in isopropanol-d8to probe the keto–enol tautomerization of the substrate (Fig.6a). In the absence of allylic alcohol, no H/D exchange at the α-sites of...
Obesity and insulin resistance are initially associated with compensatory increases in hepatic oxidative metabolism in response to lipid oversupply to the liver29; however, these conditions eventually progress to the accumulation of excess triglycerides in the liver30that contribute to MASLD. Accumulation of...
The cleavage of the carbon–carbon bond occurs by a two-step mechanism in which the hydroxide ion attacks the carbonyl carbon atom to give a tetrahedral intermediate that subsequently releases the tribromomethyl carbanion. If iodine reacts with a methyl ketone, iodoform, CHI3, forms. It is a ...
To react with succinyl-CoA, the C-2 position of glycine in the enzyme-bound glycine–pyridoxal-5′-phosphate complex must be converted into a stabilized carbanion or equivalent nucleophilic species. This can, in principle, be accomplished by either a decarboxylation or proton abstraction mechanism....
OPTICALLY ACTIVE AMINE DERIVATIVE AND METHOD OF SYNTHESIS optically active 5-hydroxyoxazolidine derivative represented by the formula (3) and an optically active amino ketone derivative represented by general formula (4) which are important intermediates for the production and to provide a method ... ...
Poly(ether ketone) Pendant groups have large effect onchain mobility. The adamantine group acts as a “fish hook” which catches on to any nearby molecule and reduces chain mobility. The magnitude of this effect is related to the size of the pendant functional group-large groups (eg. ...
Identify the class of organic compounds (ester, ether, ketone, etc.) to which the depicted compound belongs. To which class of compounds does the molecule CH3CH2OCH3 belong? A. ketone B. aldehyde C. ether D. amine E. carboxylic acid ...
stannylchlorides has also been reported. The high reactivity of the chlorine–tin bond is believed to be responsible for the activity of the reaction, assolvationinto a tightion paircould conceivably enhance the Lewis acidity of the tin center sufficiently to allow for a Type-I mechanism to ...
An Iridium/ketone dual catalysis pathway has been proposed (Fig.4c). The condensation of alkyl amine1with diazafluorenone4yields imine18, which is deprotonated at the α C−H bond to form 2-azaallyl anion1949. The delocalized carbanion19then undergoes asymmetric addition at the diazafluorenyl...