Reductive aminationSilica-supported Ni catalystNanocatalysisSustainable chemistryThe development of sustainable protocols for the reductive amination is a highly desirable pursuit in the domain of green synthesis. Magnetic nanocatalysts have found a unique niche in chemical synthesis in recent years as the ...
Reductive amination of an aldehyde or ketone with ammonia or an amine in the presence of a reducing agent, frequently hydrogen and a catalyst, is a longstanding route to amines <80RCR14>. Other reducing agents that can be used include sodium borohydride <87S709>, sodium cyanoborohydride <75S1...
Synthesis of Primary Amines:鈥First Homogeneously Catalyzed Reductive Amination with Ammonia 来自 掌桥科研 喜欢 0 阅读量: 6 作者: Thoralf Gross,Abdul Majeed Seayad,Moballigh Ahmad, and,Matthias Beller 摘要: The synthesis of primary amines via reductive amination of the corresponding carbonyl ...
The asymmetric reductive amination of achiral ketones with ammonia is a particularly attractive reaction for the synthesis of chiral amines. Although several engineered amine dehydrogenases have been developed by protein engineering for the asymmetric reductive amination of ketones,they all display(R)-...
Synthesis of primary amines: first homogeneously catalyzed reductive amination with ammonia. Org. Lett. 4, 2055–2058 (2002). Article CAS Google Scholar Gallardo-Donaire, J., Ernst, M., Trapp, O. & Schaub, T. Direct synthesis of primary amines via ruthenium‐catalysed amination of ketones ...
According to these results, it is concluded that Ru(0) cluster supported on HAP will represent a suitable catalyst for widely-usable reductive amination to convert an aldehyde functionality towards an amine. 展开 关键词: Furfural Reductive amination Furfurylamine Ru cluster Aqueous ammonia solution ...
Another useful feature of reductive amination reactions is that two (or three if one starts with ammonia) reductive aminations can be employed in sequence. For example, look at the synthesis of the tertiary amine below. Importantly, the sequence of reactions isn’t crucial here. We could have...
Amine dehydrogenase-catalyzed reductive amination of prochiral ketones with ammonia is a promising method for the synthesis of optically pure amines in the pharmaceutical and fine chemical industries. However, previously reported amine dehydrogenases show restricted catalytic capacity toward bulky ketones, whi...
Most of the short-chain alkylamines can be made by reductive amination or alkene amination, involving the reaction of alcohol, aldehyde or ketones with ammonia over a supported metal catalyst (nickel or cobalt on silica or alumina). Additionally, amines containing tertiary alkyl groups have been ...
Vysotskii, V.I. Reductive amination of 2, 2′-methylenebiscyclohexanone and its analogs with potassium borohydride and ammonia (or amines).Chem Heterocycl Compd6, 1154–1156 (1970). https://doi.org/10.1007/BF00480729 Download citation