The significance of these results relative to the mechanism of the reductive amination of carbonyl compounds with sodium cyanoborohydride and amine salts is discussed.doi:10.1016/S0040-4020(01)92446-9Jack TadanierRobert HallasJerry R. Martin
Method for producing amines by homogeneously catalyzed reductive amination of carbonyl compounds The invention relates to the preparation of chiral or achiral amines by reaction of aldehydes or ketones with ammonia or primary or secondary amines in the presence of hydrogen and in the presence of homoge...
The effects of the acidity of the carbon surface on the reactivity and selectivity of carbon supported noble metal catalysts in the reductive amination of benzaldehyde with ammonia was studied. The equilibria involved in the homogeneous solution were studied with 1H NMR. At the start of the reducti...
The given reaction illustrates an example of reductive amination, which results in the formation of 4-cyclohexylmorpholin. The complete reaction is...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tou...
However, the nucleophilic substitution of aromatic amines with benzylic halides may result in overalkylation side reactions to some extent, and despite being an efficient process, reductive amination requires the use of reactive aldehydes and reductants. Fig. 1: Summary of previous and current studies...
However, as most natural "reductive aminase" activities operate on keto acids, and many are able to use only ammonia as the amine donor, there is considerable scope for the engineering of natural enzymes for the reductive amination of ketones, and also for the preparation of secondary amines ...
Mechanism of hysteresis in bovine glutamate dehydrogenase: role of subunit interactions Hysteresis in glutamate dehydrogenase is observed only in the reductive amination reaction and only with GTP present. The rate of reductive amination with ... T Smith,JE Bell - 《Biochemistry》 被引量: 38发表: ...
Initially, we indeed considered the possibility of inner-sphere mechanism in this transformation, and a sequence of migratory insertion and reductive elimination of C–F bond finishes the product (Fig.5A). However, the poor diastereoselectivity (around 1:1, see Fig.2) in the allylic carbofluorina...
Ambient temperature chemoselective Mannich reactions of vanillin are apparently very rare.21 The isolated benzoxazines 2 thus allow for the formation of mixed systems, as in the preparation of 1k. Bis(formyl) 1e readily undergoes reductive amination with amine/pinacol·borane mixtures. ...
Photoredox nickel catalysis has emerged as a powerful strategy for cross-coupling reactions. Although the involvement of paramagnetic Ni(I)/Ni(III) species as active intermediates in the catalytic cycle has been proposed, a thorough spectroscopic investi