Reductive amination of an aldehyde or ketone with ammonia or an amine in the presence of a reducing agent, frequently hydrogen and a catalyst, is a longstanding route to amines <80RCR14>. Other reducing agents that can be used include sodium borohydride <87S709>, sodium cyanoborohydride <75S1...
REITZ: 'Reductive Aminations of Carbonyl Compounds with Borohydride and Borane Reducing Agents in Organic Reactions', 2002, JOHN WILEY AND SONSBaxter, E. W.; Reitz, A. B. Reductive Aminations of Carbonyl Compounds with Borohydride and Borane Reducing Agents; Org. React., Vol. 59; Wiley: ...
One common reducing agent for this purposes is sodium cyanoborohydride (NaBH3CN) which can selectively reduce imines in the presence of aldehydes. Many other reducing agents (NaBH4, NaBH(OAc)3, etc.) can be used as well. It’s possible to start with a primary amine and do two successive ...
The reaction of aldehydes or ketones with ammonia equivalents or primary orsecondary aminesin the presence of hydride reducing agents gives alkylated amines. The reductive amination usingsodium cyanoborohydride (NaBH3CN)as the reducing agent is especially calledthe Borch reactionand has high generality. ...
In the literature the homogenously catalyzed reductive amination reaction gets less attention than the overall HAM reaction. Industrially the reductive amination is often performed with heterogenous catalysts (Gomez et al., 2002, Heinen et al., 2000) or chemically reducing agents, in particular borohyd...
The terms “reductive amination” and “reductive alkylation” refer broadly to the reactions of aldehydes or ketones (i.e., carbonyl compounds) with ammonia, primary amines, or secondary amines in the presence of reducing agents to yield primary, secondary, or tertiary amines, respectively. Carbon...
Selective reductions with complex hydride reducing agents in methanol is very effective in the reduction of enamines, reductive amination of aldehydes and ketones, and deoxygenation of aldehdyes and ketones. The... Kim,S - 《Pure & Applied Chemistry》 被引量: 1发表: 1987年 加载更多来源...
Hydrosilanes Are Not Always Reducing Agents for Carbonyl Compounds, II: Ruthenium-Catalyzed Deprotection of tert-Butyl Groups in Carbamates, Carbonates, Es... Hydrosilanes act as a reagent to cleave the C–O bond of OtBu groups in carbamates, carbonates, esters, and ethers by catalysis of a...
Commercially available chlorodicarbonylrhodium(I) dimer was shown to be a highly active catalyst for the direct reductive amination of aldehydes and ketones. In the presence of hydrosilanes as reducing agents and under mild conditions, this new catalytic system provides easy access to secondary and ...
They have been the subject of numerous studies due to their uses as common reducing agents in organic chemistry [7–10]. There is great interest in borohydrides as hydrogen storage materials [11–14] as they offer both high volumetric and gravimetric hydrogen storage densities. Show abstract ...