REDUCTIVE AMINATION OF ALDEHYDESThe invention relates to a method for producing amines by reacting aldehydes with ammonia in the presence of hydrogen and of a hydrogenating catalyst while adding disodium tetraborate.Kiel, Wolfgang
et al.; " Reductive Amination of Aldehydes and Ketones by Using Sodium Triacetoxyborohydride "; Tetrahedron Lett., 1990, vol. 31, pp. 5595-5598.Abdelmagid, A. F.; Maryanoff, C. A.; Carson, K. G., Reductive amination of aldehydes and ketones by using sodium triacetoxyborohydride. ...
Reductiveaminationof aldehydes or ketones is an excellent method of producing amines, especially on an industrial scale. To form amino acids on a laboratory scale, the starting material is an α-keto acid. Ammonia reacts with the α-keto acid to give animine. Reduction of the imine with H2in...
ALINEZHAD, HESHMATOLLAH 等: " Reductive amination of aldehydes and ketones in a heterogeneous system in THF and under solvent-free conditions using sodium borohydride-silica phosphoric acid ", 《MONATSHEFTE FUER CHEMIE》, vol. 139, no. 1, 31 October 2007 (2007-10-31), pages 21 - 25, XP...
Ti(OiPr)4can be used as a Lewis acid to activate the ketone/aldehyde towards addition by the amine and the resulting imine can then be reducedin situby NaBH3CN, which is a reductive amination. Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct an...
reductive amination of aldehydes/ketones towards the primary amines, one needs to be able to effectively tune the hydrogenation activity and to establish a structure–performance relationship at an atomic/molecular scale. Unfortunately, for conventional nanocatalysts, the fine-tuning of their hydrogenation...
An efficient, green and reliable method for the direct reductive amination of aldehydes was developed using an environmentally benign bentonite-gold nanohybrid catalyst. Use of this heterogeneous catalyst affords a variety of secondary amines in excellent yield under ambient reaction conditions in the pres...
Robichaud A,Ajjou A N.First example of direct reductive amination of aldehydes with primary and secondary amines catalyzed by water-soluble transition metal catalysts. Tetrahedron Letters . 2006Robichand A. and Ajjou A.N., First example of direct reductive amination of al- dehydes with primary...
Reductive Amination 隐藏>> REVIEWS The Reductive Amination of Aldehydes and Ketones and the Hydrogenation of Nitriles: Mechanistic Aspects and Selectivity Control Silvia Gomez, Joop A. Peters, Thomas Maschmeyer* Laboratory of Applied Organic Chemistry and Catalysis, DelftChemTech, Delft University of Tech...
United States Patent US6429335 Note: If you have problems viewing the PDF, please make sure you have the latest version ofAdobe Acrobat. Back to full text