which is the antigenic ectodomain of measles virus hemagglutinin protein (MeaH) genetically modified not to bind to human cells; and a second component fused thereto which is capable of binding to the surface structure of genetically variable viruses such as HCV or HIV or other therapeutic targets...
PAVIRANI A ET AL: "RECOMBINANT PROTEINS OF THERAPEUTIC INTEREST EXPRESSED BY LYMPHOID CELL LINES DERIVED FROM TRANSGENIC MICE" BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 7, no. 10, 1 October 1989 (1989-10-01), pages 1049-1054, XP000054645 ISSN: 0733-222X...
Recombinant proteins including antibodies are essential tools for drug discovery in the early stage and used in a multitude of applications. While for production of therapeutic proteins criteria such as growth behavior, clonality, and stability, as well as the productivity of the producer cell line ...
The large-scale production of recombinant proteins in living cells or organisms; frequently applied to the use of crop plants or domestic animals as expression hosts because of the allusion to agriculture. HETEROLOGOUS In the context of this article, a gene or protein that is not derived from th...
Recombinant DNA technologies have enabled the selection and humanization of specific antibody fragments in order to develop therapeutic reagents of any specificity that can be 'armed' to deliver effective anti-inflammatory 'payloads'. Antibodies and antibody-like proteins provide the opportunity to block...
No staining was observed with these constructs (data not shown). In conclusion, these data show that rec41D3 allows the targeting of peptides and/or proteins towards pSn+ cells. Discussion Monoclonal antibodies and derivatives are currently the fastest growing class of therapeutic molecules [26]....
Therapeutic Proteins: Methods and Protocols. Humana Press, Totowa, NJ, pp. 107-122Chu, L., Blumentals, I., and Maheshwari, G. (2005) Production of recombinant therapeutic proteins by mammalian cells in suspension culture, in Therapeutic Proteins: Methods and Protocols , Humana Press, Totowa, ...
Recombinant antibodies have become the most common class of therapeutic proteins, and are used in the treatment of many disease areas including oncology, inflammation, and immunology. This product class is currently produced solely by mammalian cells, and although product titers are relatively low in ...
These six recombinant proteins comprised of defined non-contiguous T cell epitope regions artificially combined into single polypeptide chains have been expressed in E. coli, highly purified, and examined for their ability to bind to human cat-allergic IgE and for human T cell reactivity. Several ...
No staining was observed with these constructs (data not shown). In conclusion, these data show that rec41D3 allows the targeting of peptides and/or proteins towards pSn+ cells. Discussion Monoclonal antibodies and derivatives are currently the fastest growing class of therapeutic molecules [26]....